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" The Effects Of Beta- Glucan Rich Oat Bread On Serum Nitric Oxide and Vascular Endothelial Function In Patients With Hypercholesterolemia "
/فائزه تابش
; Masoumeh Sadeghi, Hamid Sanei
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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103459
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| Doc. No
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T14980
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| Call number
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WG,120,T113e,2014
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| Main Entry
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Tabesh, Faezeh
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| Title & Author
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The Effects Of Beta- Glucan Rich Oat Bread On Serum Nitric Oxide and Vascular Endothelial Function In Patients With Hypercholesterolemia/فائزه تابش
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| College
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Schools, Medical
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| Date
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, 2014
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| Degree
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Cardiology, Speciality
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6 p.: diag., tab.
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| Note
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This is a research dissertation with project ID 392239
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| Note
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Orginal Works
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| Abstract
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Introduction. Oats are high in soluble fibers and effective in reducing the risk of cardiovascular diseases (CVD). We assessed the effects of beta-glucan fromoat bran on serumnitric oxide (NO) endothelial function in patientswith hypercholesterolemia. Method. Sixty hypercholesterolemic patients were randomly divided to receive an experimental bread rich in beta-glucan from oat bran (intervention) or bread rich in wheat fiber (control) for four weeks. All subjects had the same diet for two-week baseline period and hypocaloric diet for four weeks of intervention. Serum NO concentration and flow-mediated dilation (FMD) were determined before and after the experiment. Results. Mean age of the participants was 51.1 +۱- 9.3 years and 65 percent ( n= 39) were female. After intervention, serum NO concentration increased by 50.2 +۱- 19.8 ..mol/lit in the intervention group (p = 0.017), but no change was observed in the control group (17.5 + ۱- 27.5 Mmol/lit; p = 0.530). No change of FMD was observed in the intervention (0.48 + ۱- 0.78 percent; p = 0.546) or in the control group (0.59 +۱- 0.92 percent ; P= 0.533). Conclusion. Consumption of oat bread for four weeks increases serum NO concentration but has no effect on FMD. Further studies are warranted in this regard.
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| Descriptor
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1. Cardiovascular Diseases.- Descriptors: Cardiovascular Diseases
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Dyslipidemias
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Endothelial Cells
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Hypercholesterolemia
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Bread
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Avena sativa
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Nitric Oxide
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| Added Entry
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Sadeghi, Masoumeh, Supervisor
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Sanei, Hamid, Supervisor
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| Translated Title Supplied by Cataloguer
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بررسی اثر نان جو بدون پیشینه بر سطح سرمی NO و عملکرد عروقی در بیماران هیپرکلسترومی
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