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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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103460
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| Doc. No
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T14979
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| Call number
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WG,340,A313i,2014
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| Main Entry
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Akhbari, Mohamadreza
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| Title & Author
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Long-term effect of renal artery sympathetic ablation and its complications in patients with treatment-resistant hypertension/ Mohamad reza Akhbari
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| College
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Schools, Medical
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| Date
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, 2014
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| Degree
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, Sub Speciality
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| field of study
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Interventional Cardiology
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| Page No
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14 p.: diag., tab.
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| Note
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This is a research dissertation with project ID 392402
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| Note
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Orginal Works
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| Abstract
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Resistant hypertension is a common clinical problem of blood pressure that is not controlled despite the simultaneous application of multiple antihypertensive agents. Ablation of renal afferent nerves, has been applied and proved to decrease the hypertension and injuries produced by severe sympathetic hyperactivity. The main objective of this study was to investigate the long-term effect of renal artery sympathetic ablation and its complications in patients with treatment- resistant hypertension. METHODS: Between March 2012 to November 2013,thirty patients with resistant arterial hypertension -despite treatment with >- 3 anhypertensive drugs- were enrolled in a Self-control clinical study. The patients were treated with the renal denervation procedure, the femoral artery was accessed with the standard endovascular technique and the Symplicity catheter was advanced into the renal artery and connected to a radiofrequency generator. Before and 24 months after renal denervation procedure waist, BMI, SBP, DBP, metabolic syndrome, FBS, HDL, and triglyceride were measured in all patients. All analyses were done using SPSS-20 statistical software, and p-values smaller than 0.05 were considered to indicate statistical significance. RESULTS: Both mean SBP and DBP were significantly decreased,24 months after renal denervation (P-values< 0.0001). The frequency of metabolic syndrome was not significantly different after renal denervation in compare to baseline (P-value = 0.17). Also, a significant decreased in FBS and triglyceride was observed in compare to baseline (P-values = 0.001). CONCLUSION: All in all, the present study highlighted the role of renal sympathetic denervation as a modern and secure catheter-based method for sustained reduction hypertensio n in treatment-resistant cases.
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| Descriptor
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Hypertension
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Vascular Resistance
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Renal Artery
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| Added Entry
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Pormoghadas , Masoud, Thesis advisor
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Khosravi , Alireza, Thesis advisor
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http://elib.mui.ac.ir/site/catalogue/103460
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