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" Initial treatment of respiratory distress syndrome with nasal intermittent mandatory ventilation versus nasal continuous positive airway pressure: A randomized controlled trial "
/قباد حیدری
; Amirmohammad Armanian, Zohre Badiee
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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103467
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| Doc. No
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T15053
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WS,410,H465i,2014
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| Main Entry
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Heidari, Ghobad
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| Title & Author
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Initial treatment of respiratory distress syndrome with nasal intermittent mandatory ventilation versus nasal continuous positive airway pressure: A randomized controlled trial/قباد حیدری
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| College
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Schools, Medical
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| Date
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, 2014
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| Degree
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Neonatology, Speciality
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28 p.: tab.
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| Note
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This thesis is a research project with project ID: 392345
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| Abstract
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Background:Neonatal respiratory distress syndrome in premature infants who survived and its complications are a common problem. Due to high morbidity with mechanical ventilation (MV) nowadays researchers interested to minimize MV. Therefore, various methods of non-invasive ventilation is developed to reduce the use of MV (which it is possible with the use of the endotracheal tube). Objective: To determine, in very low birth weight (VLBW) preterm neonates with respiratory distress syndrome (RDS), if initial treatment with nasal intermittent mandatory ventilation (early NIMV) compared with early nasal continuous positive airway pressure (early NCPAP) obtains more favorable outcomes in terms of the duration of treatment and the need for endotracheal tube ventilation. Patients and Methods: In this single-center randomized control trial study, infants (birth weight =< 1500 gr. and/or gestational age =< 34 weeks) with respiratory distress were eligible. Forty-four infants were randomly assigned to receive early-NIMV and 54 comparable infants to early-NCPAP. Surfactant was given when FIO2 requirement was of > 30percent. Primary outcomes were failure of noninvasive respiratory support (i.e., the need for mechanical ventilation (MV)) in the ?rst 48 h of life and duration of non-invasive respiratory support in each group. Results: 98 infants were enrolled (44 in the NIMV and 54 in the NCPAP groups). The Preventive power for MV of NIMV usage (95.5percent) was not lower than the NCPAP (98.1percent) strength (hazard ratio [HR]: 0.21 (95percent con?dence interval (CI): 0.02 - 2.66); P: 0.23). The duration of non-invasive respiratory support in NIMV group was significantly shorter than NCPAP (the median (Range) was 24 (18.00 - 48.00) hours vs 48.00 (22.00 - 120.00) hours in NIMV vs NCPAP groups; P <0.001). Similarly, the duration of dependency to oxygen was less with NIMV (the median (Range) was 96.00 (41.00 - 504.00) hours vs 144.00 (70.00 - 1130.00) hours in NIMV vs NCPAP groups; P 0.009). Attractively, time to full enteral feeds and length of hospital stay were more favorable in NIMV group vs NCPAP. Conclusion: Initial treatment of RDS with NIMV was safe and well tolerated. Furthermore NIMV had excellent benefits such as reduction of the duration of treatment, oxygen dependency period and length of hospital stay. Therefore primary mode with NIMV could be a feasible method of non-invasive ventilation in very premature infants.
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| Descriptor
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1. Respiratory Distress Syndrome In Premature Infants.- Descriptors: Respiratory Distress Syndrome In Premature Infants
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Ventilation
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Continuous Positive Airway Pressure
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Noninvasive Ventilation
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| Added Entry
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Armanian, Amirmohammad, Supervisor
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Badiee, Zohre, Supervisor
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| Translated Title Supplied by Cataloguer
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مقایسه اثر NCPAP با NIMV بعنوان درمان اولیه سندرم دیسترس تنفسی در نوزادان نارس کمتر از ۱۵۰۰ گرم
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