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" Short Term High Dose Atorvastatin for the Prevention of Contrast-Induced Nephropathy in Patients Undergoing Computed Tomography Angiography "
/علیرضا حاجیان نژاد
; Hamid Sanei, Amirreza Sajjadieh Kajouei
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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103468
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| Doc. No
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T14977
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| Call number
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WG,300,H154s,2014
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| Main Entry
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Hajian Nejad, Alireza
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| Title & Author
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Short Term High Dose Atorvastatin for the Prevention of Contrast-Induced Nephropathy in Patients Undergoing Computed Tomography Angiography/علیرضا حاجیان نژاد
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| College
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Schools, Medical
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| Date
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, 2014
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| Degree
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Cardiology, Speciality
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| Page No
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20 p.: diag., tab
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| Note
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This is a research dissertation with project ID: 392353
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| Abstract
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Statins are shown effective by some studies in preventing contrast-induced nephropathy (CIN). We evaluated the effectiveness of atorvastatin in the prevention of CIN in computed tomography angiography (CTA) candidates. Methods: This study was conducted on patients referring for elective CTA with normal renal function. Patients received atorvastatin (80 mg per day) or placebo from 24 hours before to 48 hours after administration of the contrast material. Serum creatinine was measured before and 48 hours after contrast material injection. CIN was defined as increase in serum creatinine level of >= 0.5 mg/dL or >= of the baseline creatinine. Results: A total of 236 patients completed the study; 115 atorvastatin, 121 placebo, mean age = 58.4 +- 9.8 year, 68.6 male. Serum creatinine increased after contrast material injection in both the atorvastatin (1.00 +- 0.16 to 1.02 +- 0.15 mg/dL, P = 0.017) and placebo groups (1.03 +- 0.17 to 1.08+- 0.18 mg/dL, P < 0.001). Controlling for age, gender, comorbidities, drug history, and baseline serum creatinine level, patients who received atorvastatin experienced less increase in serum creatinine after contrast material injection (F = 4.70, P = 0.031). However, there was no difference between the atorvastatin and placebo groups in the incidence of CIN (4.3 vs. 5.0 percent, P = 0.535) Conclusion: In patients undergoing CTA, a short-term treatment with high dose atorvastatin is effective in preventing contrast-induced renal dysfunction, in terms of less increase in serum creatinine level after contrast material injection. Further trials including larger sample of patients and longer follow-ups are warranted.
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| Descriptor
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1. Coronary Artery Diseases.- Descriptors: Coronary Artery Diseases
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Tomography, X- Ray Computed
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Angiography
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Contrast Media
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Heptanoic Acids
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| Added Entry
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Sanei, Hamid, Supervisor
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Sajjadieh Kajouei, Amirreza, Supervisor
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| Translated Title Supplied by Cataloguer
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بررسی اثر اتورواستاتین با دز بالا ( ۸۰ میلی گرم روزانه ) در پیشگیری از ایجاد نفروپاتی ناشی از کنتراست در بیماران تحت سیتی آنژیوگرافی کرونر
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