خط مشی دسترسیدرباره ما
ثبت نامثبت نام
راهنماراهنما
فارسی
ورودورود
صفحه اصلیصفحه اصلی
جستجوی مدارک
تمام متن
منابع دیجیتالی
رکورد قبلیرکورد بعدی
center : Isfahan University of Medical Sciences
Document Type : Latin Dissertation
Language of Document : English
Record Number : 103470
Doc. No : T15051
Call number : ‭WM,176,Z36t,2014‬
Main Entry : Zarean, Elham
Title & Author : Topiramate augmentation in refractory obsessive compulsive disorder: A randomized, double-blind, placebo-controlled trial/الهام زارعان
College : Schools, Medical
Date : , 2014
Degree : Psychiatry, Speciality
Page No : 21 p.: diag, tab.
Note : This thesis is a research project with project ID:391144
Abstract : Objective: This study aimed to assess the efficacy of Topiramate, a glutamate-modulating agent, in patients with treatment-resistant obsessive-compulsive disorder (OCD) as an adjunct to serotonin reuptake inhibitors (SRIs). Methods: Thirty-eight patients with refractory OCD, were randomly assigned to receive Topiramate or placebo. This study was designed as a 12-week, double-blind, placebo-controlled trial. Primary outcome measures were the change in Yale-Brown Obsessive Compulsive Scale (Y-BOCS) score and the rate of treatment response in each group at the study end point. Treatment response was considered as 25 percent or more reduction in Y-BOCS score. Results: 13 patients in the Topiramate group and 14 ones in the placebo group completed the trial. Topiramate-assigned patients showed significantly improved mean Y-BOCS score over time (p<0.001). Although differences between two groups was significant in the Y-BOCS score at the first two months (p=0.01), this was not significant at the end of study (p=0.10). Changes of Clinical Global Impression (CGI)-Severity of Illness scale score and CGI-Improvement scale score were not significantly different between two groups (p>0.05).Treatment response was almost significantly different in the Topiramate group comparing placebo group (p=0.054). Mean Topiramate dosage was 137.5 mg/day (range, 100-200). Conclusion: This study didn't show efficacy of Topiramate as an agent to augment SRIs in treatment-resistant OCD patients.
Descriptor : 1. Obsessive-Compulsive Disorder.- Descriptors: Obsessive-Compulsive Disorder
: topiramate
: therapy
Added Entry : Akouchekian, Shahla, Supervisor
: Afshar, Hamid, Supervisor
Translated Title Supplied by Cataloguer : بررسی اثربخشی افزودن توپیرامات به درمان اختلال وسواسی- جبری مقاوم به درمان
عنوان :
نام فایل :
نوع عام محتوا :
نوع ماده :
فرمت :
سایز :
عرض :
طول :
Topiramate augmentation in refractory obsessive compulsiv...
zarean elhama.pdf
پایان نامه لاتین
متن
application/force-download
40 KB
85
85