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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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103470
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| Doc. No
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T15051
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| Call number
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WM,176,Z36t,2014
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| Main Entry
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Zarean, Elham
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| Title & Author
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Topiramate augmentation in refractory obsessive compulsive disorder: A randomized, double-blind, placebo-controlled trial/الهام زارعان
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| College
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Schools, Medical
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| Date
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, 2014
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| Degree
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Psychiatry, Speciality
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| Page No
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21 p.: diag, tab.
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| Note
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This thesis is a research project with project ID:391144
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| Abstract
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Objective: This study aimed to assess the efficacy of Topiramate, a glutamate-modulating agent, in patients with treatment-resistant obsessive-compulsive disorder (OCD) as an adjunct to serotonin reuptake inhibitors (SRIs). Methods: Thirty-eight patients with refractory OCD, were randomly assigned to receive Topiramate or placebo. This study was designed as a 12-week, double-blind, placebo-controlled trial. Primary outcome measures were the change in Yale-Brown Obsessive Compulsive Scale (Y-BOCS) score and the rate of treatment response in each group at the study end point. Treatment response was considered as 25 percent or more reduction in Y-BOCS score. Results: 13 patients in the Topiramate group and 14 ones in the placebo group completed the trial. Topiramate-assigned patients showed significantly improved mean Y-BOCS score over time (p<0.001). Although differences between two groups was significant in the Y-BOCS score at the first two months (p=0.01), this was not significant at the end of study (p=0.10). Changes of Clinical Global Impression (CGI)-Severity of Illness scale score and CGI-Improvement scale score were not significantly different between two groups (p>0.05).Treatment response was almost significantly different in the Topiramate group comparing placebo group (p=0.054). Mean Topiramate dosage was 137.5 mg/day (range, 100-200). Conclusion: This study didn't show efficacy of Topiramate as an agent to augment SRIs in treatment-resistant OCD patients.
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| Descriptor
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1. Obsessive-Compulsive Disorder.- Descriptors: Obsessive-Compulsive Disorder
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topiramate
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therapy
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| Added Entry
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Akouchekian, Shahla, Supervisor
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Afshar, Hamid, Supervisor
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| Translated Title Supplied by Cataloguer
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بررسی اثربخشی افزودن توپیرامات به درمان اختلال وسواسی- جبری مقاوم به درمان
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http://elib.mui.ac.ir/site/catalogue/103470
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