خط مشی دسترسی
پرسش و پاسخ
Isfahan University of Medical Sciences
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Collagen cross-linking effect on progressive keratoconus in patient younger than 18 year old: a clinical randomized trial/علی کمالی
17 p.: tab.
This thesis is a research project with project ID: 391370
Background: Keratoconus is a bilateral non inflammatory corneal disease. Collagen cross-linking (CXL) is a new treatment of the disease by using ultraviolet A light irradiation and riboflavin administration. The aim of this study is to evaluate the effect of CXL on corneal topographic and refractive values in patients with keratoconus younger than 18 years old. Methods: For a clinical trial study, 37 patients (64 eyes) younger than 18 year old with progressive keratoconus were included. Age, sex, family history of keratoconus and history of allergic disorders and eye rubbing were recorded. All subjects were examined by slit lamp and also funduscopic examinations were done. Refractive, topographic and topometric indices were evaluated before and 12 months after the CXL. Results: Mean age (+/-SD) of the patients was 15.83+/_1.53, 26 (70.3 Percent) of them were male, 14 (37.8 Percent) had positive family history of keratoconus, 11 (29.7 Percent) had history of allergic disorders and 15 (40.5 percent) had positive history of eye rubbing. Of the refractive values, cylinder value decreased significantly from -4.50+/-0.29 to -4.11+/-0.28 (P=0.001). Also logMAR uncorrected visual acuity (UCVA) and best corrected visual acuity (BCVA) improved significantly 12 months after CXL (P=0.012 and 0.001 resp.). Maximum keratometry before and after the operation was 53.82+/-0.72 and 53.33+/-0.72 respectively (P=0.018). Differences for simulated K values, the thinnest cornea pachymetry, KI index, IHA and IHD indices before and 12 months after the CXL were statistically significant (P=0.015, 0.034, <0.001, 0.017, 0.019 and 0.004 respectively). Conclusion: According to our result, CXL improves refractory, topographic and topometric indices in patients with keratoconus younger than 18 year old.
1. Keratoconus.- Descriptors: Keratoconus
Razmjoo, Hassan, Supervisor
Peyman, Alireza, Supervisor
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Collagen cross-linking effect on progressive keratoconus ...
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