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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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103476
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| Doc. No
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T15104
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| Call number
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WG,300,D322i,2014
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| Main Entry
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Dehghani Tafti, Faezeh
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| Title & Author
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Impact of smoking on no-reflow phenomenon after pereutaneous coronary intervention in patients with acute ST elevation myocardial infarction/فائزه دهقانی تفتی
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| College
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Schools, Medical
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| Date
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, 2014
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| Degree
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Cardiology, Speciality
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| Page No
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27 p.: tab.
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| Note
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This thesis is a research project with project ID: 392317
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| Abstract
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Background: No-reflow phenomenon after percutaneous coronary intervention (PCI) in patients with acute ST-segment-elevation myocardial infarction (STEMI) is relatively common and has therapeutic and prognostic implications. On the other hand cigarette smoking is known to be deleterious in patients with coronary artery disease, but the effect of smoking on no-reflow phenomenon is less investigated. The aim of our study was to assess the impact of smoking on no-reflow phenomenon after PCI in STEMI patients.Materials and Methods: A total number of 141 patients who were admitted to Chamran Hospital (Isfahan, Iran) between March and September, 2012 with diagnosis of STEMI, enrolled into our Cohort study. Patients were divided into current smoker and non-smoker groups (based on patients information). All patients underwent primary PCI or rescue PCI Within the first 12 hours of chest pain. No-reflow phenomenon, thrombolysis in myocardial infarction (TIMI) flow and 24-hour complications were assessed in both groups. Results: 47 current smoker cases (32.9 percent) and 94 (65.7 percent) nonsmoker cases were evaluated. Smokers in comparison to non-smokers were younger (53.47 +/- 10.59 versus 61.46 +/- 10.55, P-value <0.001) and they were less likely to be hypertensive (15.2 percent versus 44.7 percent, P-value< 0.001), diabetic (17 percent versus 36.2 percent, P-value <0.05), and female gender (4.3 percent versus 25.5 percent, P-value <0.01). Angiographic and procedural characteristics of both groups were similar. 9 patients died during the first 24 hours after PCI (4.3 percent of smokers and 6.4 percent of non-smokers, P-value: 0.72). No-reflow phenomenon was observed in 29.8 percent of current smokers and 31.5 percent of non-smokers (P-value = 0.77). Smoking status and no-reflow phenomenon were not significantly correlated even after adjustments for age, gender, history of diabetes, hypertension, history of CAD and the extent of stenosis (OR = 1.68; 95 percent CI 0.68-4.10, P-value = 0.25 ).Conclusion: According to the present study, no-reflow phenomenon or short-term complications were not significantly lower in smokers. So better results in previous studies may be explained by differences in baseline characteristics and not by smoking status itself. Current smokers developed STEMI about 8 years earlier than non-smokers with similar age and sex-adjusted risk of no-reflow phenomenon and 24 hour mortality. These results emphasize role of efforts to encourage smoking cessation as prevention of myocardial infarction.
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| Descriptor
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1. Percutaneous Coronary Intervention.- Descriptors: Percutaneous Coronary Intervention
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Smoking
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Myocardial Infarction
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No-Reflow Phenomenon
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| Added Entry
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Shemirani, Hasan, Supervisor
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| Translated Title Supplied by Cataloguer
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تاثیر سیگار بر پدیده no-reflow پس از PCI در بیماران با سکته حاد قلبی همراه با بالا رفتن ST
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http://elib.mui.ac.ir/site/catalogue/103476
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