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" does vitamin c improve endothelial function in patients with Kawasaki disease? "
/اسفندیار نجفی توانا
; Mohammad Reza Sabri
; Abdolrasoul Nikyar, Alireza Ahmadi
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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103484
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| Doc. No
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T15099
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| Call number
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WH,700,N147d,2014
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| Main Entry
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Najafi Tavana, Sfandyar
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| Title & Author
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does vitamin c improve endothelial function in patients with Kawasaki disease?/اسفندیار نجفی توانا
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| College
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Schools, Medical
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| Date
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, 2014
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| Degree
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Pedicatic Cardiology, speciality
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| Page No
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[43 p.: tab.
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| Note
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This thesis is a research project with project ID:393239
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| Abstract
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Background: Considering the importance of improvement of endothelial function in patients with type 1 diabetes mellitus (DM) and to prevent its related micro- and macro-vascular complications; in this study, the effect of vitamin C administration on improving endothelial function of children with type 1 diabetes was investigated. Methods: In this analytic-experimental study, children with type 1 DM aged 6-18 years and a group of healthy children enrolled. Vitamin C (250 mg/ daily) administrated for the two studied groups for 1-month. Endothelial function evaluated by flow-mediated dilatation (FMD) and intima-media thickness (IMT) measurement using vascular Doppler ultrasonography, before and after trial. Results: In this study, 18 patients with type 1 diabetes (DM) and 19 normal children as the control group were studied. After vitamin C administration IMT reduced in all studied groups (P < 0.05). FMD increased in all studied groups, but it was significant only in thecontrol group(p=0.02 in the control group and P=0.07 inpatients with DM). Mean differences of IMT 2 - IMT 1, FMD 2 - FMD 1 and left ventricular (LV) mass 2 - LV mass 1 and blood pressure (BP) were not significantly different in two studied groups (P > 0.05). Mean differences of IMT 2 - IMT 1, FMD 2- FMD 1, LV mass 2- LV mass 1 and BP were not significantly different in patients with HbA1c<=7 g/dl and those with HbA1c >7 g/dl and control group (P > 0.05). Conclusions: The findings of the current study indicated that vitamin C may have a protective effect on endothelial dysfunction, but regarding its effectiveness among the high-risk population such as diabetic patients with and without appropriate glycemic control th study was not sufficiently powered due to its small sample siz.
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| Descriptor
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1. Mucocutaneous Lymph Node Syndrome.- Descriptors: Mucocutaneous Lymph Node Syndrome
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Endothelium
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Ascorbic Acid
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Child
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Adolescent
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| Added Entry
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Sabri, Mohammad Reza, Supervisor
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Nikyar, Abdolrasoul, Advisor
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Ahmadi, Alireza, Advisor
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