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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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103487
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| Doc. No
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T15102
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| Call number
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WK,810,K45e,2014
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| Main Entry
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Khalilzade, Hossein
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| Title & Author
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Efficacy of bromocriptine on glycemic and metabolic control of prediabetic patients/حسین خلیل زاده
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| College
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Schools, Medical
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| Date
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, 2014
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| Degree
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Endocrinology, Specialty
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| Page No
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23 p.: tab.
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| Note
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This thesis is a research project with project ID:393043
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| Abstract
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it is suggested that bromocriptine could be effective in treatment of prediabetic patients and consequently in preventing type 2 diabetes. in this study we investigated the effectiveness of bromocriptine on glycemic and metabolic control of prediabetic patients. in this double-blind placebo controlled trial study, prediabetic patients diagnosed during Isfahan daibetes Prevention Project (IDPP) were enrolled. they randomized in two bromocriptine (2.5mg) and placebo treated groups, for 12 weeks. after physical examination, fasting plasma glucose (FPG), HbA1c insulin, cholesterol, HDL-c and triglyceride were measured and glucose tolerance test (OGTT) was performed. HOMA-IR and LDL-c were calculated. the mean of the data were compared in the bromocriptine and placebo treated groups, before and after intervention by intention to treat analysis rsing mixed effect model. in this study 53 prediabetic patients were treated. there were no differences between data of two groups at baseline. the mean body mass index, systolic blood pressure, fasting plasma glucose and glucose of 30 min, 60 min, 120 min, of post OGTT, HbA1c, insulin, HOMA_IR, lipid profile did not change, significantly, in both bromocriptine and placebo-treated groups after 12 weeks. however diastolic blood pressure and the area under the curve of glucose were decreased in bromicriptine treated group. bromocriptine did not have significant effect on glycmic control of prediabetic patients. further studies with bigger sample size is recommended.
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| Descriptor
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1. Prediabetic State.- Descriptors: Prediabetic State
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Diabetes Mellitus, Type 2
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Bromocriptine
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| Added Entry
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Aminorroaya, Ashraf, Supervisor
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Amini, Masoud, Supervisor
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http://elib.mui.ac.ir/site/catalogue/103487
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