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" Effects of progesterone and vitamin D on outcome of patients with acute traumatic spinal cord injury: a randomized, double-blind, placebo controlled study "
/اثناعشری، علی
; Bahram Aminmansour
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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103492
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| Doc. No
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T15093
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| Call number
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WL,403,A835e,2014
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| Main Entry
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Asnaashari, Ali
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| Title & Author
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Effects of progesterone and vitamin D on outcome of patients with acute traumatic spinal cord injury: a randomized, double-blind, placebo controlled study/اثناعشری، علی
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| College
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Schools, Medical
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| Date
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, 2014
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| Degree
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Neurosurgery, Specialty
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| Page No
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27 p.: Diag, tab.
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| Note
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This thesis is a research project with project ID: 391332
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| Abstract
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steroid hormones offer promising therapeutic perspectives during the acute phase of spinal cord injury while progesterone and vitamin D remain controversial. the aim of the present study was to determine the effects of progesterone and vitamin d on outcome of patients with acute traumatic spinal cord injury. this was a clinical trial including 64 adult patients with acute traumatic SCI admitted within 8 hours of injury. all the patients received methylprednisolone on admission according to standard rotocol (30 mg/kg as bolus dose and 15 mg/kg each 3 hour up to 24 hours). patients were then randomly assigned to receive intramuscular injection of 0.5 mg/kg progesterone twice daily and 5ug/kg oral vitamin D3 twice daily up to 5 days (n=32) or placebo (n=32). patients were visited 24-hour, 6 days and 3 months after injury and motor and sensory function was assessed according to american spinal injury association (ASIA) score. there was no significant difference between two study groups regarding age, gender and therapeutic approach. we did not found any significant difference between two study groups regarding the motor and sensory function of the involved segments after 24 hours, 5 days and 3 months. however the motor powers and sensory function increased significantly after 3 months in both study groups. the results of this study indicate that administration of progerterone and vitamin d in acute phase of spinal cord injury does not encompass neuroptection effects. jurther studies are required to shed light on this issue.
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| Descriptor
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1. Spinal Cord Injuries.- Descriptors: Spinal Cord Injuries
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Progesterone
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Vitamin D
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| Added Entry
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Aminmansour, Bahram, Supervisor
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