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" The diagnostic role of cervico-vaginal fluid interleukins-1 alpha in endometriosis: a case control study "
/ Zahra Sheikh-Soleimani
; farahnaz Mardanian
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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103494
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| Doc. No
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T15091
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WP,390,S543d,2014
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| Main Entry
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Sheikh Soleimani , Zahra
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| Title & Author
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The diagnostic role of cervico-vaginal fluid interleukins-1 alpha in endometriosis: a case control study/ Zahra Sheikh-Soleimani
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| College
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Schools, Medical
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| Date
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, 2014
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| Degree
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, Specialty
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| field of study
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Obstetrics and Cynecology
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22 p.: Diag, tab.
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| Note
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This thesis is a research project with project ID: 392243
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| Abstract
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Background: Endometriosis is a chronic and progressive gynecological disorder and is manifest by dysmenorrhea and a major cause of infertility and chronic pelvic pain. The study was designed to compare the value of cervico-vaginal fluid of interleukin-1 (IL-1) in patients with and without endometriosis. Materials and Methods: Fifty women were assessed in this case control study. The case group included 25 patients with endometriosis. The control group included 25 women without any evidence of endometriosis or any other genital disease. Endometriosis was confirmed by laparoscopy and histopathological examination. Cervico-vaginal fluid samples were obtained from patients during the follicular phase and preup surgery to assess the levels of IL-1 in cervico-vaginal fluid. The level of IL-1 was assessed using commercially available Avi Bionhuman Enzyme-Linked Immunosorbent Assay kits (FIN-01720, Vantaa, Finland) for IL-1. Receiver-operator curve analysis was used to estimate the power of IL-1 to distinguish subjects with endometriosis from controls. Results: The cervico-vaginal fluid level of IL-1 in cases was 210.44 +/- 40.11 pg/mL and in controls was 54.28 +/- 25.73 pg/mL, the differences between two groups was statistically significant (P < 0.0001). The cut-off point for cervico-vaginal fluid IL-1 for endometriosis was 105 pg/mL, with a sensitivity of 100 percent (95 percent confidence interval [CI]: 86.2-100),and specificity of 100 percent (95 percent CI: 86.2-100). Conclusion: Results show a significant increase in the cervico-vaginal fluid levels of IL-1 alpha, in women with endometriosis, that it can be a useful marker in the diagnosis of endometriosis.
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| Descriptor
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Endometriosis
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Interleukins
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Cervix Uteri
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Vagina
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| Added Entry
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Mardanian, Farahnaz, Supervisor
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| Translated Title Supplied by Cataloguer
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بررسی مقایسه ای سطح اینترلوکین I آلفا در مایع سرویکوواژینال زنان مبتلا به اندومتریوز و زنان نرمال
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