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" The effect of adding erythropoietin to intravenous methylprednisoone for the treatment of optic neuritis "
/شیما شاهزمانی
; Vahid Shayegannejad, Alireza Dehghani
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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103519
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| Doc. No
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T15149
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WW,280,S525e,2014
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| Main Entry
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Shahzamani, Shima
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| Title & Author
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The effect of adding erythropoietin to intravenous methylprednisoone for the treatment of optic neuritis/شیما شاهزمانی
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| College
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Schools, Medical
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| Date
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, 2014
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| Degree
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Neurology, Specialty
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18 p.: tab.
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| Note
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This thesis is a research project with project ID: 393131
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| Abstract
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to compare the effect of adding recombinant human erythropoietin (rhEPO) to intravenous methylprednisolone for the treatmentof optic neutitis on the logarithm of the minimm angle of resolution (logMAR), perimetric variables [mean deviation (MD) and pattern standard deviation (PSD)], and retinal nerve fiber layer (RNFL) thickness in optical coherence tomography (OCT). 30 patients (15 patients in each group) diagnosed with unilateral optic neuritis were included. all patients received 1000 mg inravenous mehylprednisolone per day for three days. one ontravenous bullous dose of rhEPO with the dose of 33000 IU was administered at days 1-3 for the patients in group 2. one intravenous bullous dose 0.9 percent of normal saline was administered at days 1-3 for group 1 patients. the patients were followed until 6 months after the intervention. in the involved eye, the final logMAR, MD, PSD and mean RNFL thickness in each of four quadrants and post intervention changes in each of the variables were compared between group 1 and group 2. the amount of MD improvement after the intervention (difference of pre- and post-intervention MDs) was significantly higher in the group 2 patinets. the other post intervention variables, including post intervention PSD amount of PSD improvement and total and four quadrant post intervention RNFL thickness and RNFL loss (difference of pre- and post intervention RNFL thicknesses), deonstrated no significant differences between group 1 and group 2. until more controlled studies are available, the rhEPO is not recommended as and add-on treatment for optic neuritis.
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| Descriptor
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1. Optic Neuritis- therapy.- Descriptors: Optic Neuritis
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Methylprednisolone
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Erythropoietin
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| Added Entry
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Shayegannejad, Vahid, Supervisor
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Dehghani, Alireza, Supervisor
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