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" The role of inflammatory processes in occurrence of left ventricular failure in patients with chronic kidney disease "
/سارا توکل
; Hassan Shemirani, Abdolamir Atapoor, Jafar Golshahi
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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103520
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| Doc. No
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T15148
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| Call number
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WJ,342,T231r,2014
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| Main Entry
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Tavakol, Sara
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| Title & Author
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The role of inflammatory processes in occurrence of left ventricular failure in patients with chronic kidney disease/سارا توکل
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| College
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Schools, Medical
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| Date
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, 2014
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| Degree
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Cardiology, Specialty
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| Page No
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15 p.: Diag., tab.
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| Note
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This thesis is a research project with project ID: 393432
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| Abstract
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recently, the relationship between increased level of inflammatory mediators such as IL6 and CRP and occurrence of left ventricular failure in patients with kidney disease has been suggested. the present study attempted to assess relationship between inflammatory mediators and occurrence of left ventricular failure in patient with chronic kidney disease. this cross-sectional study was performed at noor and hazrat aliasghar hospital in Isfahan between september 2012 to september 2013 on patients aged>19 years that referred for lollowing their chronic kidney disease. serum level of inflammatory parameters including C-reactive protein (CRP) and interleukin-6 (IL6) was measured using spectrophotometer. all patients were also assessed using M-mode echocardiography to determine left ventricular ejection fraction (LVEF). the group with significant reduce LVEF showed lower GFR when compared to the normal LVEF group (40.73+/-20.61 percent versus 44.43+/-17.98 percent, p=0.032), however no differences were found in the serum level of CRP and IL-6 between the two groups. comparing GFR across the three groups with normal LVEF (>55 percent), with mild LV dysfunction (LVEF<45 percent)showed significantly lower GFR level in latter group compared with normal LVEF and mild LV dysfunction group (p=0.026). although, the level of serum CRP was significantly higher in patients with signigicant left ventricular failure than other groups (p=0.018), but the difference in serum level of IL-6 was not significant between the three groups (p=0.420). inflammatory processes can potentially affect left ventricular function in patients with chronic kidney disease. in the regard, increaed level of CRP may be a main factor for predicting severity of left ventricular failure in these patients.
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| Descriptor
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1. Renal Insufficiency, Chronic.- Descriptors: Renal Insufficiency, Chronic
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Heart Ventricles
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Inflammation
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| Added Entry
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Shemirani, Hassan, Supervisor
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Atapoor, Abdolamir, Supervisor
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Golshahi, Jafar, Supervisor
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| Translated Title Supplied by Cataloguer
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بررسی ارتباط بین نارسایی بطن چپ با سطح فاکتورهای التهابی CRP,IL6 در مبتلایان به بیماری مزمن کلیه در شهر اصفهان در سال۱۳۹۱-۱۳۹۲
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