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" Comparison of Triamcinolone Acetonide Mucoadhesive Film with Liquorice Mucoadhesive Film on Signs, Symptoms, and Duration of ( HNC ) Radiotherapy- induced Oral Mucositis "
/فهیمه پاکروان
; Parichehr Ghalyani, Hamid Emami
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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103531
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| Doc. No
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T15197
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WU,140,P152c,2014
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| Main Entry
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Pakravan, Fahimeh
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| Title & Author
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Comparison of Triamcinolone Acetonide Mucoadhesive Film with Liquorice Mucoadhesive Film on Signs, Symptoms, and Duration of ( HNC ) Radiotherapy- induced Oral Mucositis/فهیمه پاکروان
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| College
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Schools, Dental
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| Date
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, 2014
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| Degree
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Dentistry, Speciality
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43 p.: diag, tab
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| Note
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This thesis is a research project with project ID 393009
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Orginal Works
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| Abstract
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Mucositis is a major complication of irradiation in head and neck (H&N) tumors, the addition of chemotherapy to irradiation may enhance this dose limiting problem. Licorice is a strong demulcent that had been effectively used in treatment of peptic ulcer. The main purpose of this study was to compare the therapeutic safety and efficacy of Triamcinolone acetonide (T) and Licorice (L) mucoadhesive films on oral mucositis in terms of pain control and/or ulcer treatment. Methods and Materials: the study was a double-blind, randomized prospective trial of two types of mucoadhesive films in the management of oral mucositis occurred during HNC radiotherapy. Oral mucositis was assessed using a quantitative scale (WHO scales) and symptoms were assessed using visual analogue scales (VAS). 60 patients were enrolled in the study: 30 patients in the Triamcinolone and 30 in the Licorice group. Results: with respect to visual analogue scores, repeated observations in consecutive weeks showed a meaningful difference (p-value < 0.05), suggesting the efficacy of both T and L. in reducing pain during radiotherapy. Comparison of the pain scores between two groups by independent sample t test, however, demonstrated no meaningful difference in any consecutive week. Conclusions: we concluded that both triamcinolone mucoadhesive films and licorice mucoadhesive films are effective in the management of oral mucositis during radiotherapy. And comparison of the pain scores between two groups demonstrated no meaningful difference, although an overall trend to reduced oral discomfort was seen in the licorice group.
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| Descriptor
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Stomatitis
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Mouth Mucosa
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Triamcinolone Acetonide
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Chemoradiotherapy
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Ghalyani, Parichehr, Supervisor
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Emami, Hamid, Supervisor
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| Translated Title Supplied by Cataloguer
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بررسی مقایسهای اثر فیلم مخاط چسب تریامسینولون استوناید و فیلم مخاط چسب شیرین بیان بر طول دوره و علایم موکویت دهانی ناشی از رادیوتراپی سر و گردن
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