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center : Isfahan University of Medical Sciences
Document Type : Latin Dissertation
Language of Document : English
Record Number : 103535
Doc. No : T15218
Call number : ‭WF,553,M894c,2015‬
Main Entry : Mosayebian, Ali
Title & Author : Comparison of the frequency of R381Q functional variant of IL-23 receptor gene, in asthmatic patients and control group/علی مسیبیان
College : Schools, Medical
Date : , 2015
Degree : Immunology, MA
Page No : k,63 p.: ill, tab
Note : This thesis is a research project with project ID 392433
Note : Orginal Works
Abstract : the interlukin-23 (IL-23)/T helper (Th) 17 cell axis plays a dey role in the developmentof inflammatory diseases such as asthma. the IL-23 receptor (IL-23R), expressed on activated T cells particularly on Th17 cells. it has been reported that a functional single-nucleotide polymorphism (SNP) (Arg381Gln;rs11209026; 1142 G wild type - A reduced function) in the Il-23R gene decreases IL-23-dependent IL-17 production. R381Q in the IL-23R chain influence IL-23 receptor signaling and consequently Th17 response. the purpose of the present study was to investigate the association between a functional SNP, IL-23R R381Q, and astham. this study was performed on 209 patients and 200 normal controls. PCR-PFLP applied to determine R381Q variant of IL-23R in all subjects. PCR products were chosen at random for reverse sequencing. our results indicated that the genotype and allele frequencies of the IL-23R R381Q polymorphism is significantly different between asthmatic patients and control subjects in Isfahan population (P value= 0.001; odd ratio=0.266; CI=95 percent). the present study suggested that R381Q polymrphism in IL-23 receptor may be a protective allele for asthem.
Descriptor : Asthma
: Polymorphism, Genetic
: Polymorphism, Single Nucleotide
: Interleukins
: Interleukin-23
Added Entry : ganjali Khani Hakemi, Mazdak, Supervisor
: Samadi, Morteza, Supervisor
: Khan Ahmad, Hossein, Supervisor
: Ghasemi, Ramin, Advisor
: Hosseini, Mohsen, Advisor
Translated Title Supplied by Cataloguer : بررسی مقایسه ای قراوانی جهش کارآمد ‭R381Q‬ در ژن پذیرنده ‭IL-23‬ در جمعیت مبتلایان به آسم و گروه شاهد
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