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" Comparison of the frequency of R381Q functional variant of IL-23 receptor gene, in asthmatic patients and control group "
/علی مسیبیان
; Mazdak Ganjali Khani Hademi, Morteza Samadi, Hossein Khan Ahmad
; Ramin Ghasemi, Mohsen Hosseini
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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103535
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| Doc. No
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T15218
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| Call number
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WF,553,M894c,2015
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| Main Entry
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Mosayebian, Ali
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| Title & Author
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Comparison of the frequency of R381Q functional variant of IL-23 receptor gene, in asthmatic patients and control group/علی مسیبیان
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| College
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Schools, Medical
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| Date
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, 2015
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| Degree
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Immunology, MA
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| Page No
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k,63 p.: ill, tab
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| Note
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This thesis is a research project with project ID 392433
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| Note
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Orginal Works
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| Abstract
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the interlukin-23 (IL-23)/T helper (Th) 17 cell axis plays a dey role in the developmentof inflammatory diseases such as asthma. the IL-23 receptor (IL-23R), expressed on activated T cells particularly on Th17 cells. it has been reported that a functional single-nucleotide polymorphism (SNP) (Arg381Gln;rs11209026; 1142 G wild type - A reduced function) in the Il-23R gene decreases IL-23-dependent IL-17 production. R381Q in the IL-23R chain influence IL-23 receptor signaling and consequently Th17 response. the purpose of the present study was to investigate the association between a functional SNP, IL-23R R381Q, and astham. this study was performed on 209 patients and 200 normal controls. PCR-PFLP applied to determine R381Q variant of IL-23R in all subjects. PCR products were chosen at random for reverse sequencing. our results indicated that the genotype and allele frequencies of the IL-23R R381Q polymorphism is significantly different between asthmatic patients and control subjects in Isfahan population (P value= 0.001; odd ratio=0.266; CI=95 percent). the present study suggested that R381Q polymrphism in IL-23 receptor may be a protective allele for asthem.
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| Descriptor
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Asthma
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Polymorphism, Genetic
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Polymorphism, Single Nucleotide
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Interleukins
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Interleukin-23
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| Added Entry
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ganjali Khani Hakemi, Mazdak, Supervisor
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Samadi, Morteza, Supervisor
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Khan Ahmad, Hossein, Supervisor
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Ghasemi, Ramin, Advisor
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Hosseini, Mohsen, Advisor
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| Translated Title Supplied by Cataloguer
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بررسی مقایسه ای قراوانی جهش کارآمد R381Q در ژن پذیرنده IL-23 در جمعیت مبتلایان به آسم و گروه شاهد
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