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" Semen Parameters and Chromatin Packaging in Microsurgical Varicocelectomy Patients "
/ Farinaz Fotouhi
; Mohammad Mardani, Mohammadhossein Nasr Esfahani
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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103755
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| Doc. No
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T15439
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| Call number
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WJ780,F761s,2015
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| Main Entry
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Fotouhi, Farinaz
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| Title & Author
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Semen Parameters and Chromatin Packaging in Microsurgical Varicocelectomy Patients/ Farinaz Fotouhi
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| College
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Schools, Medical
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| Date
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, 2015
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| Degree
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Medicine, MD
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[ Various Paging ]: tab
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| Note
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This thesis is a research dissertation with project ID 393796
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فریناز فتوحی
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| Abstract
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Background: Varicocelectomy is considered as standard treatment for male infertility for clinicalvaricocele. The aim of this study is to address the effects of varicocelectomy on semen parameters,chromatin packaging, and pregnancy outcome.Materials and Methods: This retrospective study was carried out between June 2006 and February 2011 on 145 infertile men with grade II or III varicocele. Microsurgical varicocelectomy was performed as part of patient management. Sperm count, motility, morphology, and chromatin packaging were assessed with a Makler counting chamber, light microscopy, Papanicoulaou and chromomycin A3 (CMA3) staining, respectively. In addition, we assessed spontaneous clinical pregnancy and miscarriage rates. Results: The percentages of spontaneous cumulative pregnancies post-surgery were 33.1% (3 months), 42.06% (6 months), 46.2% (9 months), 48.9% (12 months), and 55.8% (after 12 months). Percentages of spontaneous cumulative miscarriage post-surgery were 2.46% (3 months), 4.93% (6 months), 4.93% (9 months), 6.17% (12 months), and 6.17 % (after 12 months). Both sperm parameters improved and the percentage of sperm protamine deficiency decreased significantly after varicocelectomy.Conclusion: These results confirm that varicocelectomy improves sperm parameters and chromatin packaging, thereby improving the chance of pregnancy. Positive aspects of this study include the large number of patients studied, duration of follow up, one surgeon who performed all of the surgeries, and type of surgery (microsurgery). The spontaneous pregnancy results also suggest that if pregnancy is not achieved within twelve months post-surgery, an alternative approach such as assisted reproductive technology (ART) treatment should be considered.
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| Descriptor
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Varicocele- surgery
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Semen
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Chromatin
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| Added Entry
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Mardani, Mohammadl, Supervisor
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Nasr Esfahani, Mohammadhossein, Supervisor
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| Translated Title Supplied by Cataloguer
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بررسی تغییرات پارامتری اسپرم، دسته بندی کروماتین در بیماران پس از جراحی واریکوسل به روش میکروسکوپی
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