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" The effect of add-on memantine on global function and quality of life in schizophrenia: a randomized, double-blind, controlled, clinical trial "
/Maryam Mohammadian
; Victoria OmraniFard
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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104534
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| Doc. No
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T15517
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WM203,M697e,2015
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| Main Entry
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Mohammadian, Maryam
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| Title & Author
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The effect of add-on memantine on global function and quality of life in schizophrenia: a randomized, double-blind, controlled, clinical trial/Maryam Mohammadian
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| College
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Schools, Medical
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| Date
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, 2015
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| Degree
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Psychiatry, Speciality
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18 p.: diag., tab.
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| Note
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This is a research dissertation with project ID 392220
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مریم محمدنیا
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| Abstract
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Background: Schizophrenia severely influences function and quality of life. The benefit of newer antipsychotics in improving the quality of life in schizophrenia still remains controversial. Several reports suggested the administration of memantine in schizophrenia. The aim of the present study is to evaluate the effect of memantine on global function and quality of life in patients with schizophrenia.Methods and Material: This was a randomized controlled trial on inpatient cases of schizophrenia in Noor university hospital, Isfahan, Iran. The diagnosis was based on clinical interview and DSM-IV-TR criteria. A number of 64 patients were selected through sequential sampling; patients were randomly allocated in intervention and placebo groups. The intervention group was treated with memantine plus previously administered, stabled-dose, atypical antipsychotic, while the control group received placebo plus previously administered, stabled-dose, atypical antipsychotic. Memantine administration was initiated at 5 mg daily; the dosage was increased at weekly intervals by 5 mg and finally up-titrated to 20 mg daily within 4 weeks. All patients were assessed by means of GAF and QLS initially and every four weeks to the end of the 12th week.Results: Analysis of baseline GAF and QLS scores showed no significant differences between the two groups (p=0.081 and p=0.225, respectively). During the study, GAF and QLS scores increased in both groups; however, the increase was higher in the intervention group. The difference between the two groups was statistically significant. (p<0.001 and p<0.001, respectively) Memantine was well tolerated, and side effects were not significant. Conclusion: The present study showed add-on memantine was significantly effective in improving the global function of patients as well as their quality of life.
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| Descriptor
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Schizophrenia
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Memantine
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Quality of Life
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| Added Entry
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Omranifard, Victoria, Thesis advisor
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| Translated Title Supplied by Cataloguer
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بررسی تاثیر افزودن ممانتین به درمان های معمول مبتلایان به اسکیزوفرنی بر کیفیت زندگی و عملکرد کلی این بیماران
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