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" Evaluation the effect of sodium nitroprusside on cardiopulmonary resuscitation outcomes in Guinea Pigs "
/Mohammad Montasery
; Mojtaba Mansouri
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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104563
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| Doc. No
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T15524
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WG205,M766e,2015
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| Main Entry
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Montasery, Mohammad
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| Title & Author
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Evaluation the effect of sodium nitroprusside on cardiopulmonary resuscitation outcomes in Guinea Pigs/Mohammad Montasery
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| College
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Schools, Medical
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| Date
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, 2015
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| Degree
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Anesthesiology and critical care, Speciality
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| Page No
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[ No Paging]: diag., tab.
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| Note
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This is a research dissertation with project ID 393011
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محمد منتصری
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| Abstract
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Background: The success rate of cardiopulmonary resuscitations (CPR) was very low during more than half a century and only a few of them had no neurological complications this study aimed to evaluation the effect of sodium nitroprusside on cardiopulmonary resuscitation outcomes in Guinea pigs.Methods: In this randomized clinical trial, 22 Guinea pigs randomly were divided in two groups of A and B. The required drugs of standard CPR were prepared and two sample drugs with the names of A (placebo) and B(Sodium nitro perusside) were used for resuscitation. For all samples CPR processes were recorded, but in the samples that reached to ROSC the data related to O2sat, Etco2, HR and type of heart rhythm at the time of ROSC were recorded five and ten minutes after ROSC. At the nd, the level of pig brain function was recorded at half, 6, 12 and 24 hours after ROSC.Results: HR at baseline in controls was higher, after resuscitation, min 5 and min 10 in cases was a little higher but he differences were not statistically significant at baseline, after resuscitation, min 5 and min 10 (P > 0.05). Etco2 at baseline, after resuscitation, min 5 and min 10 among controls were higher with no significant difference (P > 0.05,). The differences in Spo2 between groups were not significant at baseline, after resuscitation, min 5 and min 10, whereas, after resuscitation and min 5 in controls was a little higher, and in min 10 in cases it was a little higher (P > 0.05). Conclusion: Administration of sodium nitroprusside during standard CPR in animal model after 8 minutes of untreated VF did not improved the rate of ROSC compared to standard CPR and other outcomes
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| Descriptor
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Cardiopulmonary Resuscitation
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Nitroprusside
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Anesthesiology
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Critical Care
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Intensive Care Units
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| Added Entry
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Mansouri, Mojtaba, Thesis advisor
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| Translated Title Supplied by Cataloguer
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بررسی پیامدهای استفاده از سدیم نیتروپروساید در فرآیند CPR نسبت به CPR استاندارد
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