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" Ginkgo Biloba In The Treatment Of Attention-Deficit/Hyperactivity Disorder In Children And Adolescents. A Randomized, Placebo-Controlled, Trial "
/Mehrsa Radmanesh
; Fereshteh Shakibaei
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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104572
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| Doc. No
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T15527
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| Call number
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WS350.8,.A8,R129g,2015
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| Main Entry
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Radmanesh, Mehrsa
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| Title & Author
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Ginkgo Biloba In The Treatment Of Attention-Deficit/Hyperactivity Disorder In Children And Adolescents. A Randomized, Placebo-Controlled, Trial/Mehrsa Radmanesh
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| College
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Schools, Medical
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| Date
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, 2015
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| Degree
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Psychiatry, Speciality
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| Page No
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18 p.: diag., tab.
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| Note
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This is a research dissertation with project ID 393287
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مهرسا رادمنش
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| Abstract
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Background: Evidence on the efficacy and safety of herbal medicines in treatment of attention-deficit/hyperactivity disorder (ADHD) is scarce. We evaluated the efficacy of Ginkgo biloba as a complementary therapy to methylphenidate for ADHD. Methods: In a randomized controlled trial, children and adolescents with ADHD were allocated to receive methylphenidate (20-30 mg/day) plus either G. biloba (80-120 mg/day) or placebo for 6 weeks. The ADHD Rating Scale-IV (ADHD-RS-IV) parent and teacher forms were completed at baseline, week 2, and week 6. Clinical treatment response was defined by a 27% improvement from baseline in the ADHD-RS-IV. (http://www.irct.ir, registration number: IRCT2014111519958N1).Results: Sixty patients completed the study; 31 in the G. biloba and 29 in the placebo groups. The ADHD-RS-IV parent and teacher scores were significantly reduced in both groups over the study period (P < 0.001). Compared with placebo, more reduction was observed with G. biloba regarding parent rating inattention score (mean difference [CI95%] = -2.39 [-1.41 to -3.38]), parent rating total score (mean difference = -2.92 [-1.26 to -4.57]), and teacher rating inattention score (mean difference = -1.32 [-0.43 to -2.21]). Response rate was higher with G. biloba compared with placebo based on parent rating (93.5% vs. 58.6%, RR of no response [CI95%] = 0.62 [0.45 to 0.86]). Side effects were limited with no difference between the two groups (P > 0.05). Conclusions: The G. biloba is an effective and safe complementary treatment for ADHD. Further studies with longer treatment and follow-up duration are warranted in this regard
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| Descriptor
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Attention Deficit Disorder with Hyperactivity
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Plants, Medicinal
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Medicine, Traditional
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Plant Extracts
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Methylphenidate
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Child
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Ginkgo Biloba
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| Added Entry
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Shakibaei, Fereshteh Thesis advisor
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| Translated Title Supplied by Cataloguer
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جینکیو بیلوبا در درمان اختلال بیش فعالی و کمبود توجه در کودکان و نوجوانان یک مطالعه تصادفی شده پلاسبو کنترل
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