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" Outcome of Rapamycin Therapy for Post Transplant -Lymphoproliferative Disorder after Kidney Transplantation:Case Series "
\ Zeinab Ebrahimi
; Farzaneh Ashrafi, Shahrzad Shahidi, Mojgan Mortazavi
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Isfahan University of Medical Sciences
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Latin Dissertation
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English
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| Record Number
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104598
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| Doc. No
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T15532
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WJ368,E16o,2015
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| Main Entry
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Ebrahimi, Zeinab
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| Title & Author
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Outcome of Rapamycin Therapy for Post Transplant -Lymphoproliferative Disorder after Kidney Transplantation:Case Series\ Zeinab Ebrahimi
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| College
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Schools, Medical
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| Date
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, 2015
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| Degree
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Medicine, MD
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No paging: tab
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This is a research dissertation with project ID:394157
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زینب ابراهیمی
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| Abstract
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BACKGROUND:Post-transplant lymphoproliferative disorders (PTLD) are a complication of chronic immunosuppressive therapy in solid organ transplantation with a high mortality rate. Alternative treatments such as rapamycin have been explored.METHODS:A detailed retrospective analysis was performed according to data collected from 13 patients with PTLD. At the time of PTLD diagnosis, immunosuppressive therapy was decreased and rapamycin administered. Overall survival, disease-free survival of patients and graft survival were determined.RESULTS:Among 590 kidney transplant recipients, 13 adult patients with PTLD were included in this study. The mean age of the patients was 42.15 (range: 25-58) years at the time of PTLD diagnosis, and 9 patients were male. Histology was distributed in 9 diffuse large B cell, 1 Malt lymphoma, 1 Burkitt lymphoma, 2 Hodgkin-like PTLD. The response rate to rapamycin alone was 30.8%. The mean overall survival period was 23.38 months and 11 patients are still alive. In total, 10 patients (76.9%) achieved a complete remission with functioning graft in 11 (84.6%) patients.CONCLUSION:Despite the retrospective focus and limited number of patients, this study provides promising results regarding the effectiveness of stopping calcineurin inhibitors and switching to rapamycin for patients with PTLD
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| Descriptor
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Kidney Transplantation
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Sirolimus
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Lymphoproliferative Disorders
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Drug Therapy
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Ashrafi, Farzaneh, Thesis advisor
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Shahidi, Shahrzad, Thesis advisor
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Mortazavi, Mojgan, Thesis advisor
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| Translated Title Supplied by Cataloguer
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بررسی اثر شیوع راپامایسین و میزان پاسخ به درمان بیماران مبتلا به لنفوم بعد از دریافت پیوند کلیه در طی سالهای ۱۳۷۰-۱۳۹۱
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