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" Comparison of the frequency of TIM-1 5383-5397ins/del and TIM3 -1541 CT polymorphism in patients with Multiple sclerosis and healthy controls "
/Fariba Mazrouei
; Mazdak Ganjali Khani Hakemi, Rasoul Salehi, Hamid Zarkesh
; Fereshte al Saheb Fosool, Masoud Etemadifar
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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104644
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| Doc. No
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T15540
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| Call number
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QU500,M476c,2015
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| Main Entry
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Mazrouei, Fariba
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| Title & Author
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Comparison of the frequency of TIM-1 5383-5397ins/del and TIM3 -1541 CT polymorphism in patients with Multiple sclerosis and healthy controls/Fariba Mazrouei
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| College
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Schools, Medical
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| Date
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, 2015
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| Degree
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Immunology, M.A
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| Page No
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k,47 p.: ill, tab
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| Note
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This thesis is a research dissertation with project ID 392266
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| Note
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Orginal Works
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| Abstract
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Introduction Multiple sclerosis (MS) is an organ-specific autoimmune disease in central nervous system, affecting about 2.5 million people around the world. Probable involvement of two newly identified immunoregulator molecules, TIM-1 and TIM-3, has been reported in autoimmune diseases. In this study, for the first time the association of TIM-1 5383-5397ins/del and TIM-3 -1541C>T polymorphisms with multiple sclerosis in Isfahan population was considered.Material and Methods.This study performed on 142 patients as case group and 142 healthy people as control group. SSP-PCR and RFLP-PCR methods applied for genotyping of TIM-1 5383-5397 ins/del and TIM-3 -1541C>T respectively. Data analysis was done by SPSS 16.0 software.Results: The results of our study showed that there is no significant association between TIM-1 5383-5397ins/del and multiple sclerosis (P=0.38), however the frequency of CT genotype of TIM-3 -1541C>T in patient group was significantly higher than the control group and there was a significant association between CT genotype and multiple sclerosis (P = 0.009, OR = 4.08).Conclusion: In overall our findings in this study show an association between TIM-3 -1541C>T and no association of TIM-1 5383-5397 ins/del with MS disease.
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| Descriptor
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Polymorphism, Genetic
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Polymorphism, Single Nucleotide
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Multiple Sclerosis
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Receptors, Interleukin
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| Added Entry
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Ganjali Khani Hakemi , Mazdak, Thesis advisor
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Salehi, Rasoul Thesis advisor
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Al Saheb Fosool, Fereshteh, Consulting advisor
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Etemadifar, Masoud, Consulting advisor
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| Translated Title Supplied by Cataloguer
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در افراد مبتلا به مولتیپل اسکلروزیس در مقایسه با افراد سالم در جمعیت اصفهان TIM-3-1541CT
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