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" The comparative study of intravenous ondansetron and sub-hypnotic propofol dose in control and treatment of intrathecal sufentanil-induced pruritus in elevtive caesarean surgery "
\ Akram Zavaran Hosseini
; Anahita Hirmanpour, Azim Honarmand
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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104961
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| Doc. No
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T15590
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| Call number
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WO184,Z39c,2015
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| Main Entry
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Zavaran Hosseini, Akram
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| Title & Author
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The comparative study of intravenous ondansetron and sub-hypnotic propofol dose in control and treatment of intrathecal sufentanil-induced pruritus in elevtive caesarean surgery\ Akram Zavaran Hosseini
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| College
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Schools, Medical
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| Date
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, 2015
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| Degree
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Medicine, MD
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| Page No
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7p.: ill, tab
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| Note
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This is a research dissertation with project ID:393424
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اکرم زواران حسینی
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| Abstract
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Objective: Pruritus is a common and disturbing side effect of neuraxial opioids after cesarean section. The purpose of this study was to compare the efficacy of intravenous ondansetron and sub-hypnotic dose of propofol in control and treatment of intrathecal sufentanil induced pruritus in cesarean surgery. Methods: Totally, 90 parturient with American Society of Anesthesiology physical status grade I-II, undergoing spinal anesthesia with 2.5 μg sufentanil and 10 mg bupivacaine 0.5% were enrolled to this randomized, prospective, double-blind study. The women were randomly assigned to two groups who received 8 mg ondansetron or 10 mg propofol to treat pruritus grade ≥3. The patient was evaluated after 5 min and in the lack of successful treatment, the doses of two drugs repeated and if the pruritus is on-going, the exact treatment with naloxone was done. Findings: The incidence of pruritus was 69.3%. Both groups were well-matched. The peak time pruritus was 30-75 min after injection. The percentage of individuals consumed naloxone were 6.8% and 15.9% in ondansetron and propofol groups, respectively (P = 0.18). The mean score of satisfaction (according to visual analog scale criteria) was 9.09 ± 1.1 in ondansetron group and 9.3 ± 1.07 in the propofol group (P = 0.39). Conclusion: Ondansetrone and sub-hypnotic dose of propofol are both safe and well-tolerated. Due to their same efficacy in the treatment of intrathecal sufentanil-induced pruritus, they can be widely used in clinical practice.
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| Descriptor
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Postoperative Complication
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Premedication
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Ondansetron
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Hypnotics and Sedatives
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Cesarean Section
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Pruritus
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Sufentanil
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| Added Entry
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Hirmanpour, Anahita, Thesis advisor
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| Translated Title Supplied by Cataloguer
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بررسی و مقایسه تاثیر تجویز داخل وریدی اندانسترون و دوز ساب هیپنوتیک پروپوفل در کنترل درمان خارش ناشی از تجویز سوفنتانیل اینتراتکال در اعمال جراحی سزارین الکتیو
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