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" Effects of cumin on nonalcoholic steatohepatitis: A double blind, randomised, controlled trial "
\ Masoumeh Torki
; Ahmad Shavakhi
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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105000
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| Doc. No
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T15599
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WI700,T683e,2015
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| Main Entry
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Torki, Masoumeh
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| Title & Author
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Effects of cumin on nonalcoholic steatohepatitis: A double blind, randomised, controlled trial\ Masoumeh Torki
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| College
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Schools, Medical
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| Date
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, 2015
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| Degree
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Internal Medicine, Speciality
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| Page No
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various Papers. : tab
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| Note
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This is a research dissertation with project ID: 392545
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معصومه ترکی
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| Abstract
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This study was designed to evaluate the effect of cumin on nonalcoholic steatohepatitis (NASH) in compare to placebo.MATERIALS AND METHODS:One hundred patients with histopathological diagnosis NASH in two groups of case and control received oral cumin capsule or placebo thrice daily for 6 months. Clinical and laboratory data were body mass index (BMI), serum triglyceride, serum total cholesterol, alanine aminotransferase (ALT), aspartate aminotransferase (AST), high-density lipoprotein (HDL), low-density lipoprotein (LDL), fasting blood sugar (FBS), steatosis grade, and side-effects and were measured at baseline and after treatment period using standard clinical chemistry techniques. The grade of steatosis was assessed by liver sonography in 3 stages (mild, moderate and severe).RESULTS:Of 100 eligible patients during follow-up 10/50 cases and 9/50 controls were excluded. At baseline and after treatment BMI, triglyceride, cholesterol, ALT, AST, HDL, LDL, and FBS were not statistically significant between groups (P ≥ 0.5). BMI, triglyceride, cholesterol, ALT, AST, LDL, and FBS after treatment decreased compare to baseline but were not statistically significant (P ≥ 0.5). The mean of changes in the level of BMI, triglyceride, cholesterol, ALT, LDL and FBS were not statistically significant (P ≥ 0.5). The mean of changes in AST and HDL between groups was significant (P < 0.05). The grade of steatosis before and after treatment between studied groups was not statistically significant (P ≥ 0.5). Side-effects were not statistically significant among the two groups.CONCLUSION:Findings show that there the effect of cumin in in the treatment of NASH was not significantly different in compare to placebo.
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| Descriptor
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Fatty Liver
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Non-alcoholic Fatty Liver Disease
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Cuminum
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Plants, Medicinal
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| Added Entry
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Shavakhi, Ahmad Thesis advisor
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| Translated Title Supplied by Cataloguer
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بررسی تاثیر زیره بر بیماران مبتلا به استئاتوهپاتیت غیر الکلی NASH بیمارستان الزهرا ( س ) اصفهان در سال 1392
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