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" The effect of infliximab (anti TNFα) on skin flap survival in rabbits "
\ Omid Youdofnezhad
; Mehdi Rasti
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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105012
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| Doc. No
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T15602
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WR600,Y82e,2015
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| Main Entry
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Yousofnezhad, Omid
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| Title & Author
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The effect of infliximab (anti TNFα) on skin flap survival in rabbits\ Omid Youdofnezhad
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| College
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Schools, Medical
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| Date
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, 2015
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| Degree
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Plastic Surgery , Sub Speciality
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| Page No
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13 p.: ill, diag, tab
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| Note
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This is a research dissertation with project ID:393787
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امید یوسف نژاد
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| Abstract
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Purpose: this study aimed to determine the effect of infliximab ( anti TNFα) on skin flap survival in rabbits due to known effects of TNFα in creation of inflammation and necrosis in flap and effectiveness of anti TNFα drugs in treatment of some diseases.Material and methods: In an experimental study with cross over design, two groups of rabbits were studied. In the first stage, marking port was done on the back of 4 rabbits from the midline of spinal in behind and right side and neck wall of fal 1 with proximal base with ratio of 1 to 6 half 2*12 cm with scalpel of above flaps was gotten up from each rabbit in front and subcutaneous surface. At the end of surgery, 5 mg/kg of infliximab was injected in intervention group and any drug was injected in the control group. Also the necrosis level and macroscopic living tissue in all 8 flaps were measured and after recording results, the flaps were transferred to pathology laboratory for microscopic study. Results: Average of the level of living flap in 8 studying rabbits showed that in 8 regions which were under infliximab injection in two stages of project, were respectively 5/93± 1/27 and 7/1± 2/58 cm (p=0.44) according to T-repaired. Also, the average of living flap level in 8 samples without infliximab injection in two above stages was respectively 4/1± 1/55 and 5/33± 3/79 (p=0.53).Conclusion: Infliximab injection can considerably help in increasing level of living flap in living tissue of rabbit by neutralizing TNFα and preventing the tissue necrosis. However, due to limitations of this study,
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| Descriptor
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Skin Transplantation
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Infliximab
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Necrosis
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Inflammation
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Rabbits
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| Added Entry
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Rasti, Mehdi Thesis advisor
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| Translated Title Supplied by Cataloguer
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بررسی اثر اینفلکسی مب بر روی بقای فلپ پوست در خرگوش ها
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