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" Effect of ondansetron on prevention of post-induction hypotension in elderly patients undergoing general anesthesia: A randomized, double-blind placebo-controlled clinical trial "
/ MohammadAli Saadati
; Mahmoud Saghaei, Mohammad Golparvar
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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105078
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| Doc. No
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T15616
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WO234,S111e,2015
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| Main Entry
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Saadati, Mohammad Ali
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| Title & Author
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Effect of ondansetron on prevention of post-induction hypotension in elderly patients undergoing general anesthesia: A randomized, double-blind placebo-controlled clinical trial/ MohammadAli Saadati
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| College
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Schools, Medical
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| Date
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, 2015
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| Degree
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Anesthesiology, Speciality
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[ No Paging]: tab.
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| Note
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This is a research dissertation with project ID 393598
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محمد علی سعادتی
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| Abstract
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Background: Elderly patients are susceptible to post-induction hypotension. Volumeloading and vasopressors for prevention of hypotension in elderly patients may increaseperioperative cardiovascular risks. Ondansetron by blocking Bezold–Jarisch refl ex (BJR)through inhibition of serotonin receptors has been effective in the prevention of postspinalhypotension, and bradycardia. Bradycardia frequently accompanies post-inductionhypotension in elderly patients, which signifi es a possible preventing role for ondansetron.No previous study has evaluated the prophylactic effects of ondansetron for the preventionof post-induction hypotension. Materials and Methods: In this randomized placebocontrolledclinical trial, ondansetron 4 mg was given intravenously to 65 elderly patients,20 min before induction of general anesthesia, and the rate of post-induction hypotensiondefi ned as 25% or more reduction in mean arterial blood pressure, compared with aplacebo groups. Results: A total of 114 patients completed the study (58 in ondansetronand 56 in the placebo group). Proportions of post-induction hypotension were 9 (16%)and 25 (45%) in ondansetron and placebo groups, respectively, (P = 0.001). Forty-fi vepatients (40%) developed bradycardia. Rates of bradycardia were not signifi cantly differentbetween two groups. Conclusions: The results of this study show the effectiveness ofintravenous ondansetron for prevention of post-induction hypotension in elderly patients.The mechanism of this effect largely is unknown. Role of ondansetron for prevention ofpost-induction hypotension may not fully understandable by its interaction with BJR, ashas been shown in post-spinal hypotensio
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| Descriptor
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Preanesthetic Medication
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Ondansetron
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Hypotension
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Aged
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Anesthesia, General
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| Added Entry
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Saghaei, Mahmoud, Thesis advisor
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Golparvar, Mohammad, Thesis advisor
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| Translated Title Supplied by Cataloguer
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بررسی تاثیر پروفیلاکتیک اندانسترون وریدی جهت جلوگیری از افت فشارخون به دنبال القاء بیهوشی در افراد مسن
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