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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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105127
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| Doc. No
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T15622
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| Call number
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WD380,S187e,2015
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| Main Entry
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Samadi, Golnaz
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| Title & Author
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Evaluation of the association of anti-C1q and lupus activity in patients with SLE referred to Alzahra hospital in one year period/ Golnaz Samadi
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| College
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Schools, Medical
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| Date
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, 2015
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| Degree
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Internal Medicine, Speciality
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| Page No
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30 p: tab.
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| Note
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This is a research dissertation with project ID 392118
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گلناز صمدی
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| Abstract
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Objectives: A prospective cohort was conducted to investigate the association of anti-C1q antibody and lupus/lupus nephritis (LN) flare. Methods: Sixty-nine consecutive patients with systemic lupus erythematosus were enrolled and followed up for 18 months. Anti-C1q was recorded at the first visit and at the time of flare. For patients with flare, age and sex matched SLE patients were considered as the control group (nested case-control study). The predictability of anti-C1q and other laboratory indices for LN flare during the 18-month follow-up was calculated. Results: 14/69 (20%) had lupus flare. 14 patients were chosen as controls. 9 cases and 3 controls had positive anti-C1q at the first visit (P=0.0001). 26 (38%) and 43 (62%) patients had positive and negative anti-C1q antibody at the first visit, respectively, of whom 9 (34.5%) and 3 (7%) patients developed LN flare in the next 18 months (P=0.003). Anti-C1q and 24-hour urine protein were found as the main predictors of LN flare. The positive and negative predictive values of anti-C1q for LN flare were 35% and 93%, respectively. Predictive values of positive anti-C1q/low C3 together were 60% and 96%, respectively. Conclusion: The combination of positive anti-C1q/low C3 had the highest reasonable predictive values for LN flare
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| Descriptor
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Lupus Erythematosus, Systemic
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Antibodies
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| Added Entry
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Fatemi, Ali Mohammad, Thesis advisor
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| Translated Title Supplied by Cataloguer
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ارزیابی ارتباط فعالیت ضد C1q در بیماران مبتلا به اریتماتوز منتشر مراجعه کننده به بیمارستان الزهرا در یک سال گذشته
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http://elib.mui.ac.ir/site/catalogue/105127
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