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" The effect of vitamin D administration on treatment of anemia in End Stage Renal Disease patients with vitamin D deficiency on hemodialysis: a placebo controlled double blind clinical trial "
\ Danial Gholami
; Afsoon Emami Naini
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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105225
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| Doc. No
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T15631
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WJ342,G427e,2015
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| Main Entry
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Gholami, Danial
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| Title & Author
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The effect of vitamin D administration on treatment of anemia in End Stage Renal Disease patients with vitamin D deficiency on hemodialysis: a placebo controlled double blind clinical trial\ Danial Gholami
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| College
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Schools, Medical
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| Date
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, 2015
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| Degree
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Internal Medicine, Speciality
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| Page No
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20 p.: diag, tab
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| Note
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This is a research dissertation with project ID:292280
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دانیال غلامی
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| Abstract
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Chronic Kidney Disease (CKD) is a progressive and irreversible loss of renal function. Anemia is one of the main complications of ESRD which is linked closely with other complications of the disease. The primary therapy for anemia in these patients is Erythropoietin. The goal of this study was to find the effect of vitamin D administration in addition to the appropriate dose of Erythropoietin in ESRD patients with vitamin D deficiency. This was a Double Blind Clinical Trial on 64 ESRD patients undergoing hemodialysis in Amin and Noor hospitals of Isfahan, Iran. The patients were divided into two groups of control and intervention. The intervention group was given vitamin D supplements and the control group received placebo. The required dose of Erythropoietin to reach the target Hemoglobin was measured and statistically analyzed.A total number of 32 female and 32 male included in this study. All the patients in treatment group aged between 18 and 76 and the patients in control group were between 21 to 76 years old. There was a significant statistical relationship between vitamin D administration and the required dose of Erythropoietin in both groups (p=0.013). But there was not a correlation between the concentration of Hemoglobin and serum vitamin D levels.Based on the main finding of this study, the relationship between vitamin D administration and required dose of Erythropoietin; It seems that the predicted dose of vitamin D prescribing strategy in K/DOQI guidelines is not adequate to achieve normal serum vitamin D in ESRD patients.
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| Descriptor
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Kidney Failure, Chronic
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Vitamin D
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Renal Dialysis
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Anemia
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Erythropoietin
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| Added Entry
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Emami Naini, Afsoon, Thesis advisor
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| Translated Title Supplied by Cataloguer
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اثر تجویز ویتامین D در درمان کم خونی در بیماران پایان مرحله بیماری کلیوی با کمبود ویتامین D تحت همودیالیز : یک شاهد دارونما کارآزمایی بالینی دو سوکور
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