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" Correlation of N-terminal pro-B-type natriuretic peptide levels and cardiac magnetic resonance imaging T2* in patients with β-thalassaemia major "
\ Elham Fahami
; Valiollah Mehrzad, Amirreza Sajjadieh Khajouei
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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105303
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| Doc. No
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T15629
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WH170,F157c,2015
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| Main Entry
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Fahami, Elaheh
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| Title & Author
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Correlation of N-terminal pro-B-type natriuretic peptide levels and cardiac magnetic resonance imaging T2* in patients with β-thalassaemia major\ Elham Fahami
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| College
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Schools, Medical
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| Date
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, 2015
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| Degree
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Internal Medicine, Speciality
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15p.: tab
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This is a research dissertation with project ID:393212
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الهام فهامی
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| Abstract
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Background. Cardiac death secondary to myocardial iron toxicity occurs in 50% of patients with transfusion-dependent β-thalassaemia major. N-terminal pro-B-type natriuretic peptide (NT-proBNP) seems to be a useful tool for early detection of cardiac haemosiderosis. We designed this study to determine whether plasma NT-proBNP levels are predictive of cardiac iron concentration, based on heart T2* assessment by magnetic resonance imaging (MRI).Materials and methods. We evaluated plasma NT-proBNP levels in 50 patients with β-thalassaemia major, aged 18 to 46 years, with preserved left ventricular systolic function, all of whom had undergone cardiac MRI within 3 months before the study. Next, three groups were defined based on heart T2* value as: group A, patients without evidence of cardiac iron overload (T2*>20 ms); group B, patients with mild to moderate cardiac iron overload (10 ms<T2*<20 ms); group C, patients with severe cardiac iron overload (T2*<10 ms).Results. NT-proBNP level was not similar among the three groups (p=0.03), being significantly higher in patients in group C (1,104.2±350.5 pg/mL) than in patients in group B (565.9±116.9 pg/mL, p=0.03) or group A (563.5±162.5 pg/mL, p=0.04). The analyses indicate that NT-proBNP levels did not correlate with cardiac iron concentrations (r=0.152, p=0.148).Discussion. Based on our study, measurements of NT-proBNP levels are not sufficient for early detection of cardiac iron overload. However, NT-proBNP measurements might be used as a tool to guide iron chelation therapy in patients with severe cardiac iron overload. The determination of their clinical use still requires multicentre studies.
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| Descriptor
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beta-Thalassemia
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Death
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Magnetic Resonance Imaging
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Magnetic Resonance Angiography
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Natriuretic Peptide, Brain
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Iron Overload
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Mehrzad, Valiollah, Thesis advisor
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Sajjadieh Khajouei, Amirreza, Thesis advisor
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| Translated Title Supplied by Cataloguer
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بررسی ارتباط سطح آمینو-ترمینال پروپپتید ناتریورتیک مغزی و رزونانس مغناطیسی قلببی تی ۲ در بیماران بتاتالاسمی ماژور
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