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" Evaluation the frequency of the peripheral blood CD4+FoxP3+ regulatory T cells expressing the lymphocyte activation gene 3 (LAG-3; or CD223) in the Multiple sclerosis patients before and after treatment with Fingolimod "


center : Isfahan University of Medical Sciences
Document Type : Latin Dissertation
Language of Document : English
Record Number : 105749
Doc. No : T16381
Call number : QW525.5,S447e,2016
Main Entry : Sedaghat, Nahid
Title & Author : Evaluation the frequency of the peripheral blood CD4+FoxP3+ regulatory T cells expressing the lymphocyte activation gene 3 (LAG-3; or CD223) in the Multiple sclerosis patients before and after treatment with Fingolimod\ Nahid Sedaghat
College : Schools, Medical
Date : , 2016
Degree : Immunology, Medical, MS
Page No : 63p.:ill, diag, tab
Note : This is a research dissertation with project ID: 392566
Abstract : IntroductionMultiple sclerosis (MS) is an autoimmune disease in which seems there is a defect in regulatory cells. It is thought that regulatory T cells expressing lymphocyte Activation Gene3 (LAG-3), and encounter effectively with the effector lymphocytes and endow a suppressor activity to these cells during the regulatory T cell homeostasis. This thesis aimed to evaluate the frequency of the peripheral blood CD4+FoxP3+LAG-3+ T cells before and after 1 month of Fingolimod treatment. Materials and MethodsBlood samples were obtained from 20 patients with Relapsing Remitting Multiple sclerosis (RRMS) before and after 1 months of Fingolimod treatment, and from 12 age-matched healthy control individuals. The frequency of regulatory T cells expressing the LAG-3 was determined by the flow cytometry method.ResultsThe frequency of the peripheral blood CD4+FoxP3+ regulatory T cells in the MS patients compared to baseline increased (P= 0.002). In addition, Fingolimod increased significantly the peripheral blood regulatory T cells expressing the LAG-3, (P= 0.005).
Descriptor : Lymphocyte Activation
: Multiple Sclerosis, Relapsing-Remitting
: Fingolimod Hydrochloride
: Immunosuppressive Agents
: Gene Expression
Added Entry : Zarkesh Esfahani , Hamid, Thesis advisor
: Alsahebfosoul, Fereshteh, Thesis advisor
: Etemadifar , Masood, Consulting advisor
Translated Title Supplied by Cataloguer : بررسی فراوانی سلول های تی تنظیمی در خون محیطی بیماران مبتلا به مالتیپل اسکلروزیس قبل و بعد از درمان با داروی فینگولیمود
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Evaluation the frequency of the peripheral blood CD4+FoxP...
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