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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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105751
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| Doc. No
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T16382
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| Call number
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QW541,M697a,2016
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| Main Entry
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Mohammadi, Nabi Allah
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| Title & Author
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Association of the HLA-G gene 14bp INS/DEL (rs16375) polymorphism and sHLA-G ‚IL-10 levels in patients with Relapsing Remitting Multiple Sclerosis (RRMS) in Isfahan province\ Nabi Allah Mohammadi
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| College
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Schools, Medical
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| Date
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, 2016
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| Degree
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Immunology, Medical, MS
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| Page No
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68p.:ill, diag, tab
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| Note
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This is a research dissertation with project ID: 392568
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| Abstract
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Human Leukocyte Antigen G (HLA-G) gene polymorphism and expression rate haverecently been suggested to have a potential role in susceptibility to Multiple Sclerosis (MS), achronic inflammatory demyelinating and neurodegenerative disease of the central nervoussystem with unknown etiology. The aim of this study was to investigate the association of thefrequency of HLA-G gene 14bp insertion/deletion polymorphism and its plasma level to MSsusceptibility. In this study, HLA-G gene from 212 patients and 210 healthy individuals wasamplified using real time PCR and screened for the 14bp insertion/deletion polymorphism. Inaddition, HLA-G plasma level of the patients were measured and compared to normalcontrols by ELISA method. Our results revealed that 14bp insertion in HLA-G could result inlower plasma HLA-G level of the subjects, regardless their health status and vice versa.Additionally, significant correlation of HLA-G genotype and its plasma level to MSsusceptibility was observed. In conclusion, not only HLA-G 14bp insertion/deletionpolymorphism could be associated to expression rate of the HLA-G gene and its plasmalevel, but also could be considered as a risk factor for susceptibility to MS in our study population
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| Descriptor
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Immunity, Innate
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Multiple Sclerosis, Relapsing-Remitting
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HLA-G Antigens
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Polymorphism, Genetic
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| Added Entry
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Adib, Minoo, Thesis advisor
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Alsahebfosoul, Fereshteh, Thesis advisor
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Etemadifar, Masoud, Consulting advisor
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Kazemi, Mohammad, Consulting advisor
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| Translated Title Supplied by Cataloguer
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ارتباط پلی مورفیسم ۱۴ bp INS/DELژن HLA-G و سطح سرمی sHLA-G و IL-۱۰ در بیماران مبتلا به RRMS استان اصفهان
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http://elib.mui.ac.ir/site/catalogue/105751
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