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" Endothelial dysfunction state in migraine headache and neurally mediated syncope in children and young adults "
\ Shiva Khalifehsoltani
; Mohammad Reza Sabri
; Omid Yaghini, Jafar Nasiri
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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105836
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| Doc. No
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T16392
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| Call number
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WL344,K45e,2015
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| Main Entry
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Khalifehsoltani, Shiva
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| Title & Author
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Endothelial dysfunction state in migraine headache and neurally mediated syncope in children and young adults\ Shiva Khalifehsoltani
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| College
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Schools, Medical
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| Date
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, 2015
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| Degree
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Pediatric, Speciality
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| Page No
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20p.:ill, tab
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| Note
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This is a research dissertation with project ID:393525
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شیوا خلیفه سلطانی
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| Abstract
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Background: Recent evidences have supported migraine headache and neurally mediated syncope as the especial types of endotheliopathies. To determine endothelial function in patients with migraine headache or those with neurally mediated syncope, the present study was conducted. Methods: This cross-sectional study was performed on 93 consecutive patients aged 5 to 20 years in four groups; neurally-mediated syncope, migraine, both neurally-mediated syncope and migraine, and control groups. All subjects were tested for basic and biophysical and biochemical features including age, gender, body mass index (BMI), systolic and diastolic blood pressures,Intima Media Thickness (IMT) and Flow-Mediated Dilatation (FMD) , blood hemoglobin, fasting blood glucose, lipid profile, intercellular adhesion molecule (ICAM), vascular cell adhesion molecule (VCAM) and E-Selectin. Results: The mean levels of VCAM and ICAM were significantly higher in all groups when compared to control group (p<0.05). Flow-mediated dilation (FMD) was significantly higher in syncope, migraine and, syncope and migraine groups than in the control group (p<0.05). Furthermore, mean intima-media thickness (IMT) was significantly lower in migraine and also in syncope and migraine groups than in syncope group and control group (p<0.05). Examining association between IMT and other baseline parameters showed positive association of IMT with systolic and diastolic blood pressures. Conclusion: Endothelial dysfunction is seen in both migraine headache and neurally mediated syncope. Changes in endothelial functional indices are also dependent to the blood pressure.
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| Descriptor
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Migraine Disorders
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Syncope
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Endothelium, Vascular
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Headache
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Carotid Intima-Media Thickness
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Syncope, Vasovagal
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Child
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| Added Entry
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Sabri, Mohammad Reza, Thesis advisor
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Yaghini , Omid, Consulting advisor
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Nasiri , Jafar, Consulting advisor
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| Translated Title Supplied by Cataloguer
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اختلال عملکرد اندوتلیال در سردرد میگرنی و سنکوپ عصبی با واسطه در کودکان و بزرگسالان جوان
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