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" Comparative Analysis of the detection rate of abnormal Triple and Quadry Tests with Amniocentesis, and Determining Maternal and Fetal Outcomes: IRAN_ISFAHAN 2012-2015 "
/ Leila Mousavi seresht
; Minoo Movahedi
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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106115
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| Doc. No
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T16444
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| Call number
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WQ209,M932c,2015
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| Main Entry
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Mousavi seresht, Leila
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| Title & Author
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Comparative Analysis of the detection rate of abnormal Triple and Quadry Tests with Amniocentesis, and Determining Maternal and Fetal Outcomes: IRAN_ISFAHAN 2012-2015/ Leila Mousavi seresht
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| College
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Schools, Medical
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| Date
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, 2015
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| Degree
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Obstetric and Gynecology, Speciality
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| Page No
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14p.: diag, tab
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| Note
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This is a research dissertation with project ID: 393186
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لیلا موسوی سرشت
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| Abstract
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Background: Today prenatal diagnostic procedures are very important. Main functions of these procedures are on the neural tubes defections, and different Aneuploidies like Down syndrome. it is recommended by American college of obstetrics and gynecology2013, depending on the available tests, physicians should determine which methods meet the needs of patient in the best way. Due to our new governmental screening protocol in Iran, different Triple and Qadry tests are done widely to recognize chromosomal abnormalities of fetus. Present study has been done with the purpose of abnormal results comparative analysis of Triple and Qadry tests with Amniocentesis, and determining Maternal and fetal outcomes.Material& methods: Present research is a descriptive-analytic study, which has been performed in Isfahan in 2012-2015. Pregnant women age of 16 and more, single pregnancy, gestational age 15- 20 weeks with Positive Triple or Qadry tests, completed informed consent and were entered the study. Then maternal serum markers including AFP, HCG, Unconjugated Estriol, and inhibin-A were measured by blood tests.Results: 4.4% of cases suffered from Down syndrome fetus and 14.8% cases suffered from pregnancy complications and 26% women had genetic risk factors. The result of T1 test of 45 persons were more than 0.004, with sensitivity=0.957. Blood factor average of T21 in mothers whose Amniocentesis were positive, is 0.7976 and in mothers whose test were negative, it is 0.0208, which is statistically significant (Pvalue=0.001). T18 and Down syndrome test were positive in 5 subjects, Down syndrome is very low (sensitivity=0.111).Conclusion: The results of T21 test showed that the sensitivity of this test in assessing down risk is very high so that very few cases remained non-recognized by this test. Therefore, this test (T21) is very strong in recognizing possible cases. It should be noted that the amount of T21 tests in down fetus is significantly more than healthy fetus.
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| Descriptor
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Prenatal Diagnosis
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Maternal Serum Screening Tests
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Amniocentesis
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Down Syndrome
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Pregnancy Complications
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Pregnancy Outcome
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| Added Entry
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Movahedi , Minoo, Thesis advisor
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| Translated Title Supplied by Cataloguer
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بررسی مقایسه ای ابنورمال تریپل و کوادری تست با آمینوسنتز در خانم های سنین باروری و مراجعه کنندگان بیمارستان های علوم پزشکی اصفهان
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