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center : Isfahan University of Medical Sciences
Document Type : Latin Dissertation
Language of Document : English
Record Number : 106151
Doc. No : T16433
Call number : ‭WI529,S163e,2015
Main Entry : Salehi, Zeinab,
Title & Author : Effect of Vitamin E onoxaliplatin-induced peripheral neuropathy prevention: A randomized controlled trial/ Zeinab Salehi
College : Schools, Medical
Date : , 2015
Degree : Radiotherapy Oncology, Speciality
Page No : 18p.: tab
Note : This is a research dissertation with project ID: 293032
: زینب صالحی
Abstract : Background : peripheral neuropathy is one of the most important limitation of oxaloplatin regimen , which frequently used for the treatment of colorectal cancer. evidence have shown that vitamin E may be protective in chemotherapy induced peripheral neuropathy . the aim of the this study is evaluating the effect of Vitamin E administration onprevention of oxaliplatin-induced peripheral neuropathy in patients with colorectal cancer . Methods : It was a prospective randomized,controlled clinical trial. Patients with colorectal cancerand scheduled to receive oxaliplatin-based regimenswere enrolled in this study.Enrolled patients were randomized into two groups . First group received vitamin Eat a dose of 400 mg daily and second group observed , until after sixth course of the oxaliplatin regimen . For oxaliplatin-inducedperipheral neuropathy assessment , we used the symptom experience diary questionnaire that completed at baselineand after sixth course of chemotherapy . Only patients with a score of zero at baseline were eligible for this study .Results: Thirty two patients were randomized to the vitamin E group and 33 to the placebo group . There was no difference in the meanperipheral neuropathy scores between two groups , after sixth course of the oxaliplatin regimen(6.37±2.85 vitamin E group , 6.57±2.94 control group ; P =0.78) .Conclusion: the results from this current trial demonstrate a lack of benefit for vitamin E in preventingOxaliplatin-induced peripheral neuropathy .
Descriptor : Colorectal Neoplasms
: Vitamin E
: Antineoplastic Agents
: Peripheral Nervous System Diseases
: Drug therapy
Added Entry : Roayaee, Mahnaz, Thesis advisor
Translated Title Supplied by Cataloguer : بررسی ویتامین ای در جلوگیری از نورروپاتی محیطی ناشی از اگزالی پلاتین در بیماران با کانسر کولورکتال درمان شده در بیمارستان حضرت سیدالشهداء اصفهان
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Effect of Vitamin E onoxaliplatin-induced peripheral neur...
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