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" Effect of Vitamin E onoxaliplatin-induced peripheral neuropathy prevention: A randomized controlled trial "
/ Zeinab Salehi
; Mahnaz Roayaee
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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English
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| Record Number
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106151
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| Doc. No
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T16433
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WI529,S163e,2015
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| Main Entry
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Salehi, Zeinab,
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| Title & Author
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Effect of Vitamin E onoxaliplatin-induced peripheral neuropathy prevention: A randomized controlled trial/ Zeinab Salehi
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| College
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Schools, Medical
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| Date
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, 2015
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| Degree
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Radiotherapy Oncology, Speciality
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| Page No
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18p.: tab
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| Note
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This is a research dissertation with project ID: 293032
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زینب صالحی
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| Abstract
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Background : peripheral neuropathy is one of the most important limitation of oxaloplatin regimen , which frequently used for the treatment of colorectal cancer. evidence have shown that vitamin E may be protective in chemotherapy induced peripheral neuropathy . the aim of the this study is evaluating the effect of Vitamin E administration onprevention of oxaliplatin-induced peripheral neuropathy in patients with colorectal cancer . Methods : It was a prospective randomized,controlled clinical trial. Patients with colorectal cancerand scheduled to receive oxaliplatin-based regimenswere enrolled in this study.Enrolled patients were randomized into two groups . First group received vitamin Eat a dose of 400 mg daily and second group observed , until after sixth course of the oxaliplatin regimen . For oxaliplatin-inducedperipheral neuropathy assessment , we used the symptom experience diary questionnaire that completed at baselineand after sixth course of chemotherapy . Only patients with a score of zero at baseline were eligible for this study .Results: Thirty two patients were randomized to the vitamin E group and 33 to the placebo group . There was no difference in the meanperipheral neuropathy scores between two groups , after sixth course of the oxaliplatin regimen(6.37±2.85 vitamin E group , 6.57±2.94 control group ; P =0.78) .Conclusion: the results from this current trial demonstrate a lack of benefit for vitamin E in preventingOxaliplatin-induced peripheral neuropathy .
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| Descriptor
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Colorectal Neoplasms
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Vitamin E
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Antineoplastic Agents
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Peripheral Nervous System Diseases
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Drug therapy
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| Added Entry
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Roayaee, Mahnaz, Thesis advisor
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| Translated Title Supplied by Cataloguer
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بررسی ویتامین ای در جلوگیری از نورروپاتی محیطی ناشی از اگزالی پلاتین در بیماران با کانسر کولورکتال درمان شده در بیمارستان حضرت سیدالشهداء اصفهان
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