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" Comparison of high dose and low dose Folic acid supplementation on prevalence, onset and severity of preeclampsia "
\ Nastaran Zamani
; Azar Danesh
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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English
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| Record Number
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106212
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| Doc. No
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T16467
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WQ215,Z23c,2015
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| Main Entry
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Zamani, Nastaran
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| Title & Author
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Comparison of high dose and low dose Folic acid supplementation on prevalence, onset and severity of preeclampsia\ Nastaran Zamani
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| College
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Schools, Medical
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| Date
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, 2015
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| Degree
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Speciality
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Obstetrics and Gynecology
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No paging: tab
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| Note
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This is a research dissertation with project ID:393587
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نسترن زمانی
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| Abstract
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Background: Folic acid supplementation had previously mentioned as a protective factor against onset of preeclampsia. In this study we aimed to compare the effect of high dose (5 mg daily) and low dose (1 mg daily) of folic acid supplementation on prevalence, onset and severity of preeclampsia.Methods and material: Pregnant women who were in first trimester were included into the study, then they were divided into two groups of 5mg and 1 mg (treated with daily 5 mg and 1 mg of folic acid respectively), both groups received folic acid from first trimester of pregnancy to 42 days after termination. Blood pressure, body mass index and some urine and blood biochemistry parameters were measured. SPSS-22 used for statistical analysis.Results: nine-hundred forty three pregnant women participated in the study (450 women in 1 mg group and 450 women in 5 mg group). Incidence rate of preeclampsia was 3.8 % in 1 mg group and 2.4% in 5 mg group. In comparison of preeclamptic patients in 1 mg and 5 mg group, no significant differences were seen regarding age, BMI, laboratory data, severity of the disease and onset (early or late) (p-value >0.05).Conclusion: Although our findings support that administration of high dose folic acid may decrease the prevalence of preeclampsia but there is not enough data to support that higher amounts of folic acid administration can reduce the severity of presentation's signs or ameliorate the laboratory data and onset of preeclampsia.
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| Descriptor
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Pre-Eclampsia
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Hypertension, Pregnancy-Induced
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Folic Acid
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| Added Entry
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Danesh, Azar, Thesis advisor
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| Translated Title Supplied by Cataloguer
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مقایسه اثر اسید فولیک با دوز بالا با اسید فولیک با دوز پایین در شروع و شدت پره اکلامپسی در سرتاسر دوران حاملگی
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