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" The Effect of Low-Dose Ketamine in Treating Acute Asthma Attack; a Randomized Clinical Trial "
/ Mahboubeh Koushkian Esfahani
; Mehrdad Esmailian
; Farhad Heidari
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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106258
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| Doc. No
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T16458
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| Call number
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WF553,K88e,2015
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| Main Entry
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Koushkian Esfahani, Mahboubeh
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| Title & Author
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The Effect of Low-Dose Ketamine in Treating Acute Asthma Attack; a Randomized Clinical Trial/ Mahboubeh Koushkian Esfahani
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| College
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Schools, Medical
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| Date
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, 2015
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| Degree
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Emergency medicine, Speciality
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| Page No
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14p.: diag, tab
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| Note
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This is a research dissertation with project ID: 393250
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محبوبه کوشکیان اصفهانی
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| Abstract
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Introduction:Efficient treatment of asthma can play an important role in controlling asthma attacks, rapid recoveryand decrease of patient mortality. Therefore, in the present study the treatment effect of low-dose ketamine is evaluated in patients with acute asthma attack.Methods: In the present single blind, randomized clinical trial with placebo control, the effect of low-dose ketamine in treating asthmatic patients presented to the emergency department is evaluated. Patients with mild to moderate asthma aged between 18 to 85 years old, without any prohibition for using ketamine and history of allergic reaction, were entered.The intervention group received 0.3, 0.4, or 0.5 mg/kg doses ofintravenous (IV)ketamine in addition to basic asthma treatments. Then the same additional dose was infused during 30 minutes. Subsequently, peak expiratory flow rate (PEFR) and the patients’ response to treatment were measured before and 1 hour after treatment. Finally, using SPSS 22.0, effectiveness of ketamine in 0.3, 0.4, and 0.5 mg/kg doses were evaluated compared to placebo.Results: 92 patients were enrolled (59.8% female, mean age 48.5 ± 13.9 years). 15 (16.3%) patients were treated with 0.3 mg/kgketamine, 14 (15.2%) with 0.4 mg/kg, and 16 (17.4%) with 0.5 mg/kg doses. Mean PEFR was 336.2 ± 101.5 liters in the placebo group and 345.8 ± 84.7 liters in the ketamine group (p = 0.6) before intervention, while after intervention, they were 352.1 ± 101.2 liters and 415.8 ± 76.2, respectively (p = 0.001). Ketamine treatment with 0.4 and 0.5 mg/kg doses led to a higher increase in PEFR compared to 0.3mg/kg dose(df: 3, 88; F = 23.8; p < 0.001). Conclusion:It seems that administration of 0.4 - 0.5 mg/kg doses of IVketamine followed by the same dose infusion during 30 minutes can be effective for rapid recovery of PEFR in mild to moderate asthma patients.
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| Descriptor
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Asthma
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Acute Disease
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Ketamine
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Peak Expiratory Flow Rate
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| Added Entry
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Esmailian, Mehrdad, Thesis advisor
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Heidari, Farhad, Consulting advisor
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| Translated Title Supplied by Cataloguer
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بررسی تاثیر کتامین با دوز پایین در درمان حمله حاد آسم در مقایسه با پلاسبو در بیماران مراجعه کننده به اورژانس مرکز آموزشی درمانی الزهرا در سال۹۳-۱۳۹۲
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