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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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106288
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| Doc. No
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T16469
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| Call number
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WC340,Z23d,2015
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| Main Entry
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Zaman, Nasim
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| Title & Author
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Does working in hospital increases seroprevalence and carrier state against Bordetella pertussis/ Nasim Zaman
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| College
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Schools, Medical
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| Date
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, 2015
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| Degree
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Speciality
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| field of study
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Infectious Diseases
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| Page No
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4p.: diag, tab
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| Note
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This is a research dissertation with project ID: 393237
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نسیم زمان
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| Abstract
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Background: Health care environments have been the setting for a number of pertussis outbreaks. Immunity after vaccination wanes overtime leading to a growing population of susceptible adolescents and adults. A number of pertussis outbreaks have occurred in hospitals resulting in transmission to health care workers (HCWs), and other patients. The aim of this study was to assess immunity status of a group of basic medical students and interns who worked in hospitals for about 4 years.Materials and Methods: In a cross‑sectional study, we measured the serum antibody titer of cases by enzyme‑linked immunosorbent assay test. All 70 subjects have received pertussis vaccine in the routine childhood vaccination schedule. All cases were healthy and had no symptoms of any respiratory diseases. We also obtained a pharyngeal culture on Bordet‑Gengou Agar for isolating Bordetella pertussis.Results: The results of B. pertussis pharyngeal culture was positive for 5 (7.1%) cases and negative for 65 (92.9%). The IgM, IgA, and IgG serum antibody was positive in 1.4%, 7.1%, and 11.4% of cases, respectively. The mean age of cases had no significant effect on serum antibody titers (P = 0.23).Conclusions: This study showed that majority of cases do not have protective serum antibody against B. pertussis. Working in hospitals does not affect seroprevalence and carrier state of B. pertussis. Immunization schedules that include no booster doses are at increased risk of pertussis. Due to the importance of the transmission in health care settings, vaccination of HCWs is a priority.
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| Descriptor
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Pertussis Vaccine
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Bordetella pertussis
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Whooping Cough
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Respiratory Tract Infections
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Healthy Worker Effect
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Seroepidemiologic Studies
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| Added Entry
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Emami, Alireza, Thesis advisor
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| Translated Title Supplied by Cataloguer
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بررسی فراوانی همزمان کشت حلق وتیتر سرمی آنتی بادی بر علیه بوردتلاپرتوسیس در دانشجویان پزشکی استاجر و کارورزان شاغل در بیمارستان های دانشگاه علوم پزشکی اصفهان در سال ۱۳۹۲
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http://elib.mui.ac.ir/site/catalogue/106288
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