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" The effect of vitamin D administration on serum leptin and adiponectin levels in End Stage Renal Disease patients on hemodialysis with vitamin D deficiency: a placebo controlled double blind clinical trial "
\ Sahar Vahdat
; Afsoon Emami Naeini
; Zahra Parin Hedayati
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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106353
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| Doc. No
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T16476
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| Call number
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Wj342,V127e,2015
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| Main Entry
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Vahdat, Sahar
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| Title & Author
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The effect of vitamin D administration on serum leptin and adiponectin levels in End Stage Renal Disease patients on hemodialysis with vitamin D deficiency: a placebo controlled double blind clinical trial\ Sahar Vahdat
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| College
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Schools, Medical
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| Date
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, 2015
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| Degree
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Speciality
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| field of study
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Nephrology
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| Page No
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18p.: diag, tab
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| Note
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This is a research dissertation with project ID:293286
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| Abstract
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The prevalence of vitamin D deficiency is higher in ESRD patients compared to healthy populations. This deficiency could lead to several complications with different mechanisms and might result in reduced survival in patients. Leptin and adiponectin are messenger proteins with endocrine secretion from adipocytes and various effects in cellular mechanisms. The goal of this study was to find the effect of vitamin D administration on serum levels of leptin and adiponectin in ESRD patients. This double blind randomized placebo control clinical trial was carried out on 64 ESRD patients on hemodialysis in Amin and Noor hospitals of Isfahan, Iran. Patients were categorized into two groups on control and intervention and serum levels of vitamin D, leptin and adiponectin were measured in both groups before and after the study. Intervention group were treated with vitamin D pearls while control group received placebo in the same manner. Obtained data were statistically analyzed and p≤0.05 was considered statistically significant. Participants in the study aged between 21 to 76 y/o in control group and 18-76 in treatment group. Number of men and women were both 16 and similar in two groups. The change in serum level of vitamin D was statistically significant in treatment group but not in control group. Serum level of leptin was reduced in treatment group while serum level of adiponectin increased significantly, none of these changes were statistically significant in control group. This study showed that vitamin D administration based on KDOQI guideline is associated with an increase in adiponectin and a decrease in leptin level in ESRD patients.
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| Descriptor
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Kidney Failure, Chronic
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Vitamin D
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Leptin
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Adiponectin
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Renal Dialysis
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| Added Entry
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Emami Naeini, Afsoon, Thesis advisor
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Hedayati, Zahra Parin, Consulting advisor
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| Translated Title Supplied by Cataloguer
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اثر مکمل ویتامین دی بر آدیپونکتین و لپتین در بیماران همودیالیزی دچار کمبود ویتامین دی در بیمارستانهای مراکز دانشگاهی اصفهان
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