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" Low dose peri-operative intravenous Tranexamic acid in patients undergoing total knee arthroplasty: A double-blind randomized placebo controlled clinical trial "
\ Mehdi Saneie Ataabadi
; Mehdi Motififard, Mohammad Ali Tahririan
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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106360
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| Doc. No
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T16479
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| Call number
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WE870,S194l,2015
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| Main Entry
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Saneie Ataabadi, Mehdi
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| Title & Author
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Low dose peri-operative intravenous Tranexamic acid in patients undergoing total knee arthroplasty: A double-blind randomized placebo controlled clinical trial\ Mehdi Saneie Ataabadi
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| College
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Schools, Medical
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| Date
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, 2015
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| Degree
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Speciality
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| field of study
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Orthopedic
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| Page No
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16p.: diag, tab
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| Note
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This is a research dissertation with project ID:392114
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مهدی صنیعی عطاآبادی
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| Abstract
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Introduction: total knee arthroplasty (TKA) is one of the most common procedures in orthopedic surgery .The null hypothesis of this study was that TA has no effect on post-surgical bleeding in patients undergoing TKA.Materials and Methods: This study was a double-blind randomized trial. All candidates for TKA who were enrolled between January 2013 and March 2013 (a total of 95 patients) were randomly assigned to two groups. In the first group (T) patients received 500 mg of intravenous Tranexamic Acid (TA) twice (once preoperative and once 3 hours postoperative) and in the second group (P) they received slow infusion of normal saline as placebo. The primary outcome of the study was the level of Hb 48 hours after surgery. Secondary outcomes were Hb levels 6 and 24 hours after surgery, the number of units of packed cells transfused, drain output during 48 hours after surgery and duration of hospitalization. Results: Hb levels 48 hours after surgery as the primary outcome was 10.92 ± 0.97 and 10.23 ±0.98 (g/dL) in groups T and P, respectively and the difference was statistically significant(P=0.001). Statistically significant differences were also observed in Hb levels 6 and 24 hours after surgery, the drain output 48 hours after surgery and the number of units of packed cells transfused between study groups (P<0.05). There was no significant difference in duration of hospitalization between the study groups (P= n.s).Conclusions: The low dose peri-operative intravenous TA significantly reduces blood loss, requirement for blood transfusion and drain output in patients undergoing TKA. However, duration of hospitalization did not change significantly.
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| Descriptor
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Knee Joint
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Orthopedic Procedures
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Tranexamic Acid
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Postoperative Hemorrhage
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Anesthesia, Intravenous
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| Added Entry
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Motififard, Mehdi, Thesis advisor
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Tahririan, Mohammadali, Thesis advisor
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| Translated Title Supplied by Cataloguer
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بررسی تاثیر تزریق ترانگزآمیک اسید بر کاهش میزان خونریزی در بیماران تحت عمل جراحی تعویض کامل مفصل زانو در بیمارستان کاشانی طی خرداد 91 تا 93
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