Association of the long pentraxin PTX3 gene polymorphism (rs3816527) with migraine in an Iranian population

\ Niloufar Iraji; ; Shaghayegh Haghjooy Javanmard

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center	:	Isfahan University of Medical Sciences
Document Type	:	Latin Dissertation
Language of Document	:	English
Record Number	:	106499
Doc. No	:	T16501
Call number	:	WL344,I65a,2015
Main Entry	:	Iraji, Niloufar
Title & Author	:	Association of the long pentraxin PTX3 gene polymorphism (rs3816527) with migraine in an Iranian population\ Niloufar Iraji
College	:	Schools, Medical
Date	:	, 2015
Degree	:	M.D
field of study	:	Medicine
Page No	:	No paging: tab
Note	:	This is a research dissertation with project ID: 191003
Abstract	:	been shown that migraine may be a form of sterile neurogenic inflammation. Pentaxins 3 (PTX3) has beendetected in brain during inflammatory responses. The aim of our study was to investigate the association ofrs3816527 polymorphism of the PTX3 gene and migraine in an Iranian population.Method: We included 103 newly diagnosed migraine patients and 148 healthy subjects as control group.Genomic DNA samples extracted from the peripheral blood and genotypes of PTX3 rs3816527 gene polymorphismwere determined. The patients filled out HIT-6 questionnaire as a scale to evaluate the severity of headache.Results: The genotype frequency of PTX3 was significantly different between the migraine patients and thecontrol subjects. CC variant homozygote genotype was statistically more frequent in the patients than in thecontrols (P b 0.05; OR = 1.74, 95% CI = 1.04–2.94). Also the C allele was not significantly more frequent inthe patients (P=0.096; OR=1.27, 95% CI=0.88–1.85). A separate analysis inmale and female subjects showedno significant differences between the different genotypes and phenotypes of PTX3 rs3816527 gene and susceptibilityto migraine in female subjects. Total HIT-6 score was significantly different between three PTX3 genotypes(P= 0.008).Conclusion: In conclusion our results showed the association between the PTX3 rs3816527 gene polymorphismwith susceptibility to migraine only in the male patients. Also total HIT-6 scores as a scale for assessment of theseverity were related to the PTX3 rs3816527 gene polymorphism. But this relationwas not established by headache
Descriptor	:	Migraine Disorders
	:	C-Reactive Protein
	:	Serum Amyloid P-Component
	:	Polymorphism, Genetic
Added Entry	:	Haghjooy Javanmard, Shaghayegh, Thesis advisor
Translated Title Supplied by Cataloguer	:	پیوستگی طولانی و پلی مورفیسم ژن پنتراکسین در بیماران مبتلا به میگرن در یک جمعیت ایرانی