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" رویان‌شناسی پزشکی لانگمن "


language of document : English
Material Type : طرح تحقیقاتی/ پروژه لاتین
Record number : 109229
doc. No : R3257
main entry : Ashtari, , Fereshteh
title & author : Short-term effect of high-dose vitamin D on the level of interleukin 10 in patients with multiple sclerosis: a randomized, double-blind, placebo-controlled clinical trial [research project]\ /Fereshteh AshtariHamid Zarkesh, Marjan Mansourian, Nafiseh Toghianifar , Akbar Forootan
Publication statement : Isfahan: , Esfahan University of Medical Sciences, Vice Chancellery for Research, : 2015
Physical Description : [ No Paging ]: .: diag
Notes : Project ID: 192165
Contents : عنوان به فارسی: مقایسه تاثیر دوز بالای ویتامین D3 با دوز معمول بر سطح اینترلوکین 10 در بیمران مبتلا به مولتیپل اسکروز طی یک کارآزمایی بالینی
Summary or Abstract : Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system. Vitamin D has been related to the prevention of MS and to modulating its course. Recent studies have shown the safety of high-dose vitamin D in MS.OBJECTIVE:This study compared the effects of high-dose vitamin D on interleukin 10 (IL-10) levels in MS patients in a double-blind, randomized clinical trial.METHODS:Ninety-four patients with relapsing remitting MS (RRMS) were randomized into a treatment and a placebo group. Both groups received conventional MS treatment. The intervention group received 50,000 IU of vitamin D every 5 days for 3 months. IL-10 was measured at baseline and after 3 months.RESULTS:Serum levels of IL-10 were (median ± IQR): 12.58 ± 11.97 and 10.97 ± 9.97 pg/ml in the intervention and placebo groups, respectively, at baseline (p = 0.161); after 3 months, these levels were 13.76 ± 18.95 and 11.31 ± 19.63 pg/ml, respectively (p = 0.158). The IL-10 level increased significantly after receiving high-dose vitamin D for 3 months (β = 0.737, p = 0.015 and R2 = 0.91).CONCLUSION:IL-10 levels increased significantly in RRMS patients after taking high-dose vitamin D3 for 3 months. High-dose vitamin D might be useful in promoting an anti-inflammatory state in RRMS patients
descriptor : Multiple Sclerosis
: Cholecalciferol
: Interleukin-10
added entry : Zarkesh, Hamid, Cllaborator
: Mansourian, Marjan, Cllaborator
: Toghianifar, Nafiseh, Cllaborator
: Forotan, Akbar, Cllaborator
Originating Source : IRIsfahan University of Medical Science
publication type : p
copyhttps://elib.mui.ac.ir/site/catalogue/10703
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کتابخانه مرکز مدیریت حوادث و فوریتهای پزشکی
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