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" Vitamin D status in small vessel and large vessel ischemic stroke patients; a case-control study "
\ Navid Manouchehri
; Mohammad Saadatnia
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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107382
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| Doc. No
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T16663
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WD145,M285v,2016
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| Main Entry
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Manouchehri, Navid
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| Title & Author
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Vitamin D status in small vessel and large vessel ischemic stroke patients; a case-control study\ Navid Manouchehri
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| College
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Schools, Medical
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| Date
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, 2016
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| Degree
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M.D
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| field of study
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Medicine
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14p.: tab
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| Note
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This is a research dissertation with project ID: 290030
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نوید منوچهری
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| Abstract
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Backgrounds:VitaminD insufficiency is a globally widespread issue. Recent studies have reported high prevalence of vitaminD deficiency in Middle East countries. Studies have shown negative effects of vitaminD deficiency on endothelium and related diseases such as ischemic brain stroke. Here we assessed vitaminD status in patients with different types of ischemic brain stroke and control group.Method:75 patients (49.3 % small vessel, 50.7% large vessel) and 75 controls, matched for age (68.01±10.94 vs. 67.64±10.24) and sex (42 male & 33 female) were recruited. 25(OH)D levels were measured by Chemiluminescence immunoassay. 25(OH)D status was considered as severely, moderately or mildly deficient and normal with 25(OH)D levels of less than 5, 5-10, 10-16 and >16 ng/ml respectively.Results:Mean±SE concentration of 25(OH)D in cases and controls were 17.7±1.5 and 26.9±1.6 (p<001) respectively. Mild, moderate and severe vitamin D deficiency was observed in 10.8 %, 32.4 %, 8.1 % vs. 34.3 %, 31.5 %, 9.5 % of small vessel and large vessel group respectively. 21.7% of the controls were vitamin D deficient. Vitamin D deficiency was significantly associated with higher risk for ischemic stroke, (P=0.000, OR= 7.17, 95% CI: 3.36 - 15.29).25(OH) D levels were significantly higher in control group comparing to small vessel (26.9±1.6 vs. 20.59 ± 2.6 P<0.05) and large vessel (26.9±1.6 vs. 13.4 ± 1.3 P<0.001) stroke patients. Small vessel group had significantly higher levels of vitamin D than large vessel (P<0.05). Conclusion:VitaminD deficiency significantly increases the risk of ischemic stroke, favoring the types with the pathogenesis of large vessel strokes.
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| Descriptor
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Vitamin D Deficiency
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Endothelium
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Brain Stem Infarctions
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Ischemia
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Migraine Disorders
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| Added Entry
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Saadatnia, Mohammad , Thesis advisor
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| Translated Title Supplied by Cataloguer
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مقایسه غلظت ویتامین دی در میان بیماران مبتلا به سکته ی مغزی ایسکمیک
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