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center : Isfahan University of Medical Sciences
Document Type : Latin Dissertation
Language of Document : English
Record Number : 107418
Doc. No : T17079
Call number : WJ342,A138a,2016
Main Entry : Abedini, Amin
Title & Author : Association of E-selectin with hematological, hormonal levels and plasma proteins in children with end stage renal disease\ Amin Abedini
College : Schools, Medical
Date : , 2016
Degree : M.D
field of study : Medicine
Page No : 4p.: tab
Note : This is a research dissertation with project ID: 291173
: امین عابدینی
Abstract : Background: Hypercoagulable state is a common serious problem in patients with end-stage renaldisease (ESRD). ESRD patients are in a condition of chronic inflammation. An increased level of E-selectin,“a key adhesion molecule that regulates leukocyte bindings to endothelium at damaged sites,” accompaniesthe higher risk of inflammation in ESRD patients. We aimed to investigate the possible correlation amongE-selectin as an adhesion molecule, coagulation factors, and inflammatory factors in children with ESRD.Materials and Methods: Thirty-five child patients with ESRD who had been on regular dialysis treatmentwere registered in our study. Nineteen sex- and age-matched healthy volunteers were used as the controlgroup. Laboratory tests were requested for the evaluation of hematological and biochemical parameters, andparathyroid hormone (PTH), and for coagulation state; Homocysteine, fibrinogen, protein C, and protein Swere measured.The enzyme-linked immunosorbent assay (ELISA) (Biomerica, CA, and IDS, UK). for serumE-selectin assay was provided by R and D Systems (Abingdon, UK).Results: Hemoglobin (Hb), blood urea nitrogen (BUN), creatinine, calcium, phosphorus, PTH,triglyceride (TG) concentrations in serum as well as E-selectin showed significant difference between thetwo study groups, as indeed was expected. Serum E-selectin was significantly higher (P value = 0.033) indialysis patients than in healthy subjects. E-selectin was correlated with BUN(r=0.36,P=0.042),creatinine(r=0.35 , P=0.02), phosphorus(r=0.39, P=0.018) and PTH(r=0.28, P=0.046).No association was foundfor other parameters.Conclusion: Although in our study circulating E-selectin concentration “as an inflammatory maker” isindependently positively associated with limited blood markers, for better evaluation, well-designed cohortstudies should be examined in ESRD children.
Descriptor : Kidney Failure, Chronic
: Blood Proteins
: E-Selectin
: Child
Added Entry : Gheissari, Alaleh, Thesis advisor
Translated Title Supplied by Cataloguer : ارتباط انتخاب الکتریکی سطح هورمون های خونی پلاسما پروتئین کودکان در کودکان مبتلا به بیماری های کلیوی مرحله آخر
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Association of E-selectin with hematological, hormonal le...
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