| |
| center
|
:
|
Isfahan University of Medical Sciences
|
| Document Type
|
:
|
Latin Dissertation
|
| Language of Document
|
:
|
English
|
| Record Number
|
:
|
107418
|
| Doc. No
|
:
|
T17079
|
| Call number
|
:
|
WJ342,A138a,2016
|
| Main Entry
|
:
|
Abedini, Amin
|
| Title & Author
|
:
|
Association of E-selectin with hematological, hormonal levels and plasma proteins in children with end stage renal disease\ Amin Abedini
|
| College
|
:
|
Schools, Medical
|
| Date
|
:
|
, 2016
|
| Degree
|
:
|
M.D
|
| field of study
|
:
|
Medicine
|
| Page No
|
:
|
4p.: tab
|
| Note
|
:
|
This is a research dissertation with project ID: 291173
|
|
|
:
|
امین عابدینی
|
| Abstract
|
:
|
Background: Hypercoagulable state is a common serious problem in patients with end-stage renaldisease (ESRD). ESRD patients are in a condition of chronic inflammation. An increased level of E-selectin,“a key adhesion molecule that regulates leukocyte bindings to endothelium at damaged sites,” accompaniesthe higher risk of inflammation in ESRD patients. We aimed to investigate the possible correlation amongE-selectin as an adhesion molecule, coagulation factors, and inflammatory factors in children with ESRD.Materials and Methods: Thirty-five child patients with ESRD who had been on regular dialysis treatmentwere registered in our study. Nineteen sex- and age-matched healthy volunteers were used as the controlgroup. Laboratory tests were requested for the evaluation of hematological and biochemical parameters, andparathyroid hormone (PTH), and for coagulation state; Homocysteine, fibrinogen, protein C, and protein Swere measured.The enzyme-linked immunosorbent assay (ELISA) (Biomerica, CA, and IDS, UK). for serumE-selectin assay was provided by R and D Systems (Abingdon, UK).Results: Hemoglobin (Hb), blood urea nitrogen (BUN), creatinine, calcium, phosphorus, PTH,triglyceride (TG) concentrations in serum as well as E-selectin showed significant difference between thetwo study groups, as indeed was expected. Serum E-selectin was significantly higher (P value = 0.033) indialysis patients than in healthy subjects. E-selectin was correlated with BUN(r=0.36,P=0.042),creatinine(r=0.35 , P=0.02), phosphorus(r=0.39, P=0.018) and PTH(r=0.28, P=0.046).No association was foundfor other parameters.Conclusion: Although in our study circulating E-selectin concentration “as an inflammatory maker” isindependently positively associated with limited blood markers, for better evaluation, well-designed cohortstudies should be examined in ESRD children.
|
| Descriptor
|
:
|
Kidney Failure, Chronic
|
|
|
:
|
Blood Proteins
|
|
|
:
|
E-Selectin
|
|
|
:
|
Child
|
| Added Entry
|
:
|
Gheissari, Alaleh, Thesis advisor
|
| Translated Title Supplied by Cataloguer
|
:
|
ارتباط انتخاب الکتریکی سطح هورمون های خونی پلاسما پروتئین کودکان در کودکان مبتلا به بیماری های کلیوی مرحله آخر
|
| | | | | |
| | |  |
http://elib.mui.ac.ir/site/catalogue/107418
| | | |
| | | |
|