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" Association of E-selectin with hematological, hormonal levels and plasma proteins in children with end stage renal disease "
\ Amin Abedini
; Alaleh Gheissari
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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107418
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| Doc. No
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T17079
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WJ342,A138a,2016
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| Main Entry
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Abedini, Amin
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| Title & Author
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Association of E-selectin with hematological, hormonal levels and plasma proteins in children with end stage renal disease\ Amin Abedini
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| College
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Schools, Medical
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| Date
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, 2016
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| Degree
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M.D
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| field of study
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Medicine
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4p.: tab
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| Note
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This is a research dissertation with project ID: 291173
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امین عابدینی
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| Abstract
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Background: Hypercoagulable state is a common serious problem in patients with end-stage renaldisease (ESRD). ESRD patients are in a condition of chronic inflammation. An increased level of E-selectin,“a key adhesion molecule that regulates leukocyte bindings to endothelium at damaged sites,” accompaniesthe higher risk of inflammation in ESRD patients. We aimed to investigate the possible correlation amongE-selectin as an adhesion molecule, coagulation factors, and inflammatory factors in children with ESRD.Materials and Methods: Thirty-five child patients with ESRD who had been on regular dialysis treatmentwere registered in our study. Nineteen sex- and age-matched healthy volunteers were used as the controlgroup. Laboratory tests were requested for the evaluation of hematological and biochemical parameters, andparathyroid hormone (PTH), and for coagulation state; Homocysteine, fibrinogen, protein C, and protein Swere measured.The enzyme-linked immunosorbent assay (ELISA) (Biomerica, CA, and IDS, UK). for serumE-selectin assay was provided by R and D Systems (Abingdon, UK).Results: Hemoglobin (Hb), blood urea nitrogen (BUN), creatinine, calcium, phosphorus, PTH,triglyceride (TG) concentrations in serum as well as E-selectin showed significant difference between thetwo study groups, as indeed was expected. Serum E-selectin was significantly higher (P value = 0.033) indialysis patients than in healthy subjects. E-selectin was correlated with BUN(r=0.36,P=0.042),creatinine(r=0.35 , P=0.02), phosphorus(r=0.39, P=0.018) and PTH(r=0.28, P=0.046).No association was foundfor other parameters.Conclusion: Although in our study circulating E-selectin concentration “as an inflammatory maker” isindependently positively associated with limited blood markers, for better evaluation, well-designed cohortstudies should be examined in ESRD children.
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| Descriptor
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Kidney Failure, Chronic
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Blood Proteins
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E-Selectin
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Child
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| Added Entry
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Gheissari, Alaleh, Thesis advisor
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| Translated Title Supplied by Cataloguer
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ارتباط انتخاب الکتریکی سطح هورمون های خونی پلاسما پروتئین کودکان در کودکان مبتلا به بیماری های کلیوی مرحله آخر
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