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" predicting pregnancy complications using serum pregnancy associated plasma protein A and free β human chorionic gonadotropin in the first trimester "
\ Arezoo Sadeghian
; Hatav Ghasemi Tehrani
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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107443
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| Doc. No
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T17073
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WQ240,S125p,2016
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| Main Entry
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Sadeghian, Arezoo
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| Title & Author
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predicting pregnancy complications using serum pregnancy associated plasma protein A and free β human chorionic gonadotropin in the first trimester\ Arezoo Sadeghian
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| College
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Schools, Medical
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| Date
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, 2016
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| Degree
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M.D
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| field of study
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Medicine
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| Page No
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15p.: tab
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| Note
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This is a research dissertation with project ID: 394024
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آرزو صادقیان
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| Abstract
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Background: We evaluated the possible relationship between maternal serum levels of pregnancy associated plasma protein A (PAPP-A) and free β human chorionic gonadotropin (β-hCG) and some pregnancy complications.Methods: A total of 1104 pregnant women at their first pregnancy were enrolled in the study. Serum PAPP-A and free β-hCG were measured in 9-14 weeks of gestation and patients were followed till the end of pregnancy.Results: A total of 1070 patients consisted the study population with the mean age of 28.64 ± 4.95. We found lower mean serum level of PAPP-A in patients with pregnancy complications, however the difference was only statistically significant in the category of preterm labor (1.02 versus 1.26; P=0.025). Also, the mean serum level of free β-hCG was seen to be lower in patients with pregnancy complications (except those with IUGR), although none of the differences were statistically significant (P>0.05). PAPP-A <0.4 was more frequent in patients who developed IUGR, preterm labor, and pregnancy induced hypertension (17.4% versus 1.2%, P<0.001; 13% versus 2%, P=0.013; and 17.4% versus 4%, P=0.015 respectively). On the other hand, the frequency of β-hCG<0.5 and β-hCG ≥0.5 among patients with and without pregnancy complications showed a non-significant difference between any of the groups (P>0.05).Conclusion: In this study we found that low serum levels of PAPP-A may predict developing IUGR, preterm labor, and pregnancy induced hypertension, however, low serum free β-hCG may be predictive for abortion only.
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| Descriptor
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Pregnancy Complications
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Blood Proteins
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Chorionic Gonadotropin
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Pregnancy Trimester, First
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| Added Entry
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Ghasemi Tehrani, Hatav, Thesis advisor
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| Translated Title Supplied by Cataloguer
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بررسی سطح سرمی بتا اچ سی جی آزاد در سه ماه اول بارداری به عنوان عوامل پیش گیری کننده ی برخی عوارض حاملگی
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