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center : Isfahan University of Medical Sciences
Document Type : Latin Dissertation
Language of Document : English
Record Number : 107452
Doc. No : T17071
Call number : QU107,S127g,2016
Main Entry : Saeidi, Hajar
Title & Author : Gamma-secretase inhibitor does not modulate angiogenesis in colon adenocarcinoma in obese mice\ Hajar Saeidi
College : Schools, Medical
Date : , 2016
Degree : M.D
field of study : Medicine
Page No : {No paging}: ill, diag
Note : This is a research dissertation with project ID: 190038
: هاجر سعیدی
Abstract : Abstract: Background: Notch is a signaling molecule which plays a role in angiogenesis and γ-secretase isrequired for processing of Notch. In this study, we investigated the effect of γ-secretase inhibitor (DAPT) ontumor angiogenesis in diet-induced obese mice.Methods: 18 mice were divided into three groups; control, obese (diet-induced) and obese+DAPT. After 15 weeks,the obese mice were subjected for tumor induction of CT26 colon adenocarcinoma cells (5 x 105 cells). Whenthe tumor size reached approximately 350 ± 50 mm3, half of the obese animals received DAPT (10mg/kg/day)subcutaneously. Blood samples were taken after 14 days and the tumors harvested for immunohistochemicalstaining and capillary density were reported as CD31 positive cells/mm2.Results: The obese animals had higher serum leptin and NO concentrations, while, serum VEGF and VEGFR-1 concentrationswere not different compare to control group. Administration of DAPT in obese mice signifi cantly reduced serumVEGFR-1 and leptin concentrations and increased serum NO level (p < 0.05). Capillary density in the tumors of obeseanimals was not different compare to control groups. DAPT administration could not alter capillary density in the tumors.Conclusion: Administration of DAPT in obese mice altered serum angiogenic factors, however, it could not modulatetumor angiogenesis in diet-induced obese mice (Fig. 4, Ref. 26). Text in PDF www.elis.sk.Key words: γ-secretase, obese, angiogenesis, adenocarcinoma.
Descriptor : Angiogenesis Inhibitors
: Amyloid Precursor Protein Secretases
: Colonic Neoplasms
: Adenocarcinoma
: Obesity
: Mice
Added Entry : Rashidi , Bahman , Thesis advisor
Translated Title Supplied by Cataloguer : مهارکننده گاما سکرتاز نمیتواند تنظیم کند آنژیوژنز را در آدنوکارسینومای روده در موش های چاق
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Gamma-secretase inhibitor does not modulate angiogenesis ...
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