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center : Isfahan University of Medical Sciences
Document Type : Latin Dissertation
Language of Document : English
Record Number : 107539
Doc. No : T17098
Call number : WF600,S187m,2016
Main Entry : Samaie, Vajihe
Title & Author : Methylprednisolone vs Dexamethasone in Management of COPD Exacerbation; a Randomized Clinical Trial\ Vajihe Samaie
College : Schools, Medical
Date : , 2016
Degree : Speciality
field of study : Internal Medicine
Page No : 19p.: diag, tab
Note : This is a research dissertation with project ID: 392549
: وجیهه سمائی
Abstract : Introduction: Corticosteroids are routinely used in management of chronic obstructive pulmonary disease (COPD) exacerbation. The main purpose of present study was to compare the efficacy of methyl prednisolone (MP) and dexamethasone (DXM) for this purpose.Methods: Adult COPD patients entered the present clinical trial. All patients received standard treatment on admission and were then divided into 2 groups of intravenous MP and DXM. Patients were asked to rate their shortness of breath; sputum volume and viscosity; dyspnea; cough; and general wellbeing on a 0-5 scale. Baseline parameters such as O2 saturation, arterial blood gas parameters, and white blood cell (WBC) count were compared on admission and day 7 and 14 of therapy using SPSS 22.Results: 68 patients were randomly allocated to 2 groups of 34 (82.4% male). The baseline characteristics of the two groups were similar (p < 0.05). Comparison of treatment outcomes for the 7th day showed a significant difference between the 2 groups only regarding cough (p = 0.047), HCO3 (p < 0.001), and O2 saturation (p = 0.042). On day 14 the 2 groups were different only regarding cough (p = 0.048) and sputum viscosity (p = 0.011). There was a significant difference between the two groups regarding trend of changes in dyspnea (p = 0.02; DXM >> MP) and cough (p = 0.035; MP >> DXM). There were no significant differences between the two medications regarding side effects on 7th and 14th day after treatment.Conclusion: It seems that MP and DXM have similar efficacy and side effects in treatment of COPD exacerbation and selecting drug of choice would better be based on the most prominent symptoms of patients on admission.
Descriptor : Pulmonary Disease, Chronic Obstructive
: Methylprednisolone
: Dexamethasone
Added Entry : Emami Ardestani, Mohammad, Thesis advisor
: Kalantari, Elham, Thesis advisor
Translated Title Supplied by Cataloguer : مقایسه اثر متیل پردنیزولون و دگزامتازون در درمان تشدید حاد بیماری انسدادی مزمن ریه در بیماران بستری در بخش ریه بیمارستان الزهرا اصفهان سال 1392
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Methylprednisolone vs Dexamethasone in Management of COPD...
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