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" Discrepancies Between Biopsy Gleason Score and Radical Prostatectomy Specimen Gleason Score: an Iranian Experience "
\ Maryam Mirtalebi
; Diana Taheri
; Mohammad Hossein Izadpanahi
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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107583
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| Doc. No
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T17111
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| Call number
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WJ762,M676d,2016
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| Main Entry
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Mirtalebi, Maryam
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| Title & Author
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Discrepancies Between Biopsy Gleason Score and Radical Prostatectomy Specimen Gleason Score: an Iranian Experience\ Maryam Mirtalebi
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| College
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Schools, Medical
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| Date
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, 2016
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| Degree
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Speciality
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| field of study
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Pathology
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| Page No
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16p.: diag, tab
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| Note
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This is a research dissertation with project ID: 393227
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مریم میرطالبی
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| Abstract
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Background: Considering the importance of treatment decisions for prostate cancer (PCa) and the utility of Gleason scoring system (GS) in this field, we aimed to evaluate the discrepancy between needle biopsy (NB) and radical prostatectomy(RP) GS in a series of Iranian patients with PCa undergoing prostate needle biopsy and subsequent radical prostatectomy. Methods: In this retrospective study, patients with PCa, underwent RP and also NB prior to RP were enrolled. The updated GS of both NB and RP specimens were determined and recorded for each patient. Patients were classified according to the GS as low-grade (GS; <=3+3), intermediate-grade(3+4 & 4+3) and high-grade(GS;>=8-10).The levels of agreement and discrepancy for each patients NB GS were assessed aligned with their corresponding RP GS using Kappa coefficient of agreement. Overgrading and undergrading of NB GS was determined also. Results: In this study, a total of 100 embedded RP and corresponding NB were analyzed. The rate of discrepancy for group and individual scoring of GS was 41% and 56%, respectively. The rate of under and over grading was 34% and 7% respectively. Kappa value for group and individual scoring was 0.443 and 0.411, respectively.Conclusion: The findings of our study indicated that though the agreement between NB GS and RP GS are fair to moderate but the feature of discrepancy, i.e. under grading in low and intermediate grades and over grading in high grades of NB GS, could help us for making more appropriate clinical decision specially with consideration of other biochemical and pathological factors such as the level of PSA or perineural invasion.
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| Descriptor
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Prostatic Neoplasms
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Neoplasm Grading
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Prostatectomy
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Biopsy
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| Added Entry
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Taheri, Diana, Thesis advisor
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Izadpanahi, Mohammadhossein, Consulting advisor
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| Translated Title Supplied by Cataloguer
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اختلاف بین نمونه برداری در معیار گلیسون با نمونه رادیکال پروستاتکتومی معیار گلیسون
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