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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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107613
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| Doc. No
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T17103
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| Call number
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WK250,N692e,2016
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| Main Entry
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Niknam, Nasim
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| Title & Author
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Endothelial dysfunction in patients with subclinical hypothyroidism and the effect of treatment with Levothyroxine \ Nasim Niknam
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| College
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Schools, Medical
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| Date
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, 2016
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| Degree
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Speciality
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| field of study
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Internal Medicine
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| Page No
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4p.: tab
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| Note
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This is a research dissertation with project ID: 392349
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نسیم نیکنام
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| Abstract
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Background: Subclinical hypothyroidism (SHT) may increase the risk of cardiovascular disease. Wecompared endothelial function between SHT patients and euthyroid individuals, and evaluated the effectsof levothyroxine therapy on endothelial function in the patients.Materials and Methods: In a quasi-experimental study, flow-mediated dilatation (FMD) and intima-mediathickness (IMT) were assessed in SHT patients and healthy controls (n = 25 in each group). Patients thenreceived levothyroxine (50 μg/day) for 2 months, and the FMD and IMT assessments were repeated.Results: Patients and controls were similar in IMT (0.56 ± 0.09 vs. 0.58 ± 0.08 mm, P = 0.481), but FMDwas lower in patients than in controls (4.95 ± 2.02 vs. 6.50 ± 2.57%, P = 0.011). A significant increasewas observed in FMD (4.11 ± 2.37%, P = 0.001), but not in IMT (−0.004 ± 0.020 mm, P = 0.327), afterlevothyroxine therapy among the patients.Conclusions: Patients with SHT have endothelial dysfunction which responds to levothyroxine therapy.Randomized placebo-controlled trials are needed to confirm these findings
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| Descriptor
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Hypothyroidism
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Endothelium
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Thyroxine
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Cardiovascular Diseases
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| Added Entry
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Khalili, Nooshin, Thesis advisor
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Aminoroaya , Ashraf, Thesis advisor
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| Translated Title Supplied by Cataloguer
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اختلالات اندوتلیال در ببماران با علائم کم کاری تیروئید و اثرات درمان با لووتیروکسین
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http://elib.mui.ac.ir/site/catalogue/107613
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