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center : Isfahan University of Medical Sciences
Document Type : Latin Dissertation
Language of Document : English
Record Number : 107613
Doc. No : T17103
Call number : WK250,N692e,2016
Main Entry : Niknam, Nasim
Title & Author : Endothelial dysfunction in patients with subclinical hypothyroidism and the effect of treatment with Levothyroxine \ Nasim Niknam
College : Schools, Medical
Date : , 2016
Degree : Speciality
field of study : Internal Medicine
Page No : 4p.: tab
Note : This is a research dissertation with project ID: 392349
: نسیم نیکنام
Abstract : Background: Subclinical hypothyroidism (SHT) may increase the risk of cardiovascular disease. Wecompared endothelial function between SHT patients and euthyroid individuals, and evaluated the effectsof levothyroxine therapy on endothelial function in the patients.Materials and Methods: In a quasi-experimental study, flow-mediated dilatation (FMD) and intima-mediathickness (IMT) were assessed in SHT patients and healthy controls (n = 25 in each group). Patients thenreceived levothyroxine (50 μg/day) for 2 months, and the FMD and IMT assessments were repeated.Results: Patients and controls were similar in IMT (0.56 ± 0.09 vs. 0.58 ± 0.08 mm, P = 0.481), but FMDwas lower in patients than in controls (4.95 ± 2.02 vs. 6.50 ± 2.57%, P = 0.011). A significant increasewas observed in FMD (4.11 ± 2.37%, P = 0.001), but not in IMT (−0.004 ± 0.020 mm, P = 0.327), afterlevothyroxine therapy among the patients.Conclusions: Patients with SHT have endothelial dysfunction which responds to levothyroxine therapy.Randomized placebo-controlled trials are needed to confirm these findings
Descriptor : Hypothyroidism
: Endothelium
: Thyroxine
: Cardiovascular Diseases
Added Entry : Khalili, Nooshin, Thesis advisor
: Aminoroaya , Ashraf, Thesis advisor
Translated Title Supplied by Cataloguer : اختلالات اندوتلیال در ببماران با علائم کم کاری تیروئید و اثرات درمان با لووتیروکسین
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Endothelial dysfunction in patients with subclinical hypo...
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