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" High Flow Nasal Cannula in the Treatment of Respiratory Distress Syndrome in One Day-old Neonate "
\ Shima Salehi Abari
; Ramin Iranpour, Alireza Sadeghnia
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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107700
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| Doc. No
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T17130
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| Call number
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WS410,S163h,2016
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| Main Entry
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Salehi Abari, Shima
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| Title & Author
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High Flow Nasal Cannula in the Treatment of Respiratory Distress Syndrome in One Day-old Neonate\ Shima Salehi Abari
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| College
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Schools, Medical
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| Date
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, 2016
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| Degree
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SubSpeciality
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| field of study
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Neonatology
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| Page No
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7p.: diag, tab
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| Note
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This is a research dissertation with project ID: 393515
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شیما صالحی ابری
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| Abstract
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Background: This study was carried out to compare high flow nasal cannula (HFNC) and nasalintermittent mandatory ventilation (NIMV) in respiratory support of one day-old neonates withrespiratory distress syndrome (RDS).Methods: This was a clinical trial conducted in neonatology wards of two university affiliatedhospitals from Sep 2013 to Dec 2014. Inclusion criteria were gestational age of 30 to 35 weeks,appropriate weight for gestational age, clinical signs and symptoms of RDS, and RDS suggestivechest-X ray. All patients with RDS were treated with NIMV for one day. Those requiring NIMVrespiratory support more than one day and showed the signs of respiratory distress wererandomized into two groups of NIMV and HFNC. Each group consisted of 30 patients. Outcomemeasures included chronic lung disease, mechanical ventilation, failure to treatment, the time toestablish full enteral feeding and the mortality rate. In addition, all complications were recorded.Characteristics of the two groups were compared at baseline and after the intervention.Results: Mean gestational age of patients in NIMV and HFNC groups was 31.81 (1.83) and 31.83(1.39) weeks, respectively. Distributions of sex, gestational age, height, head circumference, andApgar scores at the first and fifth minute after the birth were not significantly different between thetwo groups. Mean (SD) duration of respiratory support after the 1st day was 16.48 (7.80) hours inNIMV group and 18.46 (6.95) in HFNC group (P=0.3). Mean (SD) duration of hospitalization inNICU was 3.24 (0.68) days in NIMV group and 3.2 (0.06) in HFNC group (P=0.8). Mean (SD) agewhen oral feeding was started, was 23.37 (5.78) hours in NIMV group and 20.13 (5.38) hours inHFNC group (P=0.03). Eleven patients (36.7%) in NIMV group vs. 2 patients in HFNC grouprequired free oxygen therapy (P=0.005). No treatment failure, chronic lung disease, mechanicalventilation or endotracheal intubation was observed in any group. 100% vs. 10% in NIMV andHFNC groups, respectively, experienced grade 3 and 4 nasal mucosal damage (P<0.01).Conclusion: HFNC was more tolerable than NIMV in the treatment of RDS in premature neonates'≥30 week-old when applied after the first day of life.
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| Descriptor
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Respiratory Distress Syndrome, Newborn
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Catheters
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Ventilation
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Iranpour, Ramin, Thesis advisor
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Sadeghnia, Alireza, Thesis advisor
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| Translated Title Supplied by Cataloguer
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کانولای بینی با جریان بالا در درمان نوزادان یک روزه مبتلا به سندروم نارسایی تنفسی
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