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" Alterations in the echocardiographic parameters of the right ventricle in asymptomatic breast cancer patients during Anthracycline chemotherapy "
\ Mohammad Karimipanah
; Morteza Abdar Esfahani, Fariborz Mokarian
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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107779
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| Doc. No
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T17150
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| Call number
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WG141.5,.E2,K18a,2016
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| Main Entry
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Karimipanah, Mohammad
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| Title & Author
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Alterations in the echocardiographic parameters of the right ventricle in asymptomatic breast cancer patients during Anthracycline chemotherapy\ Mohammad Karimipanah
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| College
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Schools, Medical
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| Date
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, 2016
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Speciality
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| field of study
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Cardiology
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18p.: diag, tab
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| Note
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This is a research dissertation with project ID: 394415
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محمد کریمی پناه
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| Abstract
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Anthracycline-induced cardiotoxicity can reach to an irreversible phase, thus huge efforts have been done in order to diagnose it early enough. Due to smaller mass of right ventricle compared to left side, it is expected that the right side of the heart be influenced by anthracycline by a greater extent and in a shorter duration. The purpose of present study was to investigate the early effects of chemotherapy on right heart.MethodsThis cross sectional study was performed in Isfahan University hospitals from August 2014 to December 2015. Subjects were sixty seven breast cancer patients who were planned to receive anthracycline for the first time. Echocardiography was done before administration of anthracyclines and six month later. Parameters include Right heart sizes (RV end-diastolic dimensions, right atrium length and diameter), right ventricular fractional area change (RVFAC), index of myocardial performance (Tei index), tricuspid annular plane systolic excursion (TAPSE), pulmonary artery systolic pressure and lateral tricuspid annular early and late diastolic velocities and tissue Doppler diastolic and systolic velocities. Results Of all subjects included, forty nine patients completed the study. RVEDDs and Tei index (0.31 to 0.37) were significantly increased (P<0.001). While, RVFAC (49.83% to 43.59%) and TAPSE (18.8 to 17.7mm) decreased (P<0.001).There are significant reduction in E (57.06 to 46.59 cm/s, P<0.001), E/A ratio (1.42 to 1.18, P<0.001), E' (16.73 to 12.4 cm/s, P<0.001), E'/A' ratio (1.21 to 0.9, P<0.001) and S' (12.59 to 10.57 cm/s, P<0.001). Systolic pulmonary arterial pressure (sPAP) (20.63 to 22.24mmHg, P=0.04) increased, significantly. Conclusion Results of this study showed significant decrease in RV systolic and diastolic functions during chemotherapy for six months. This reductions were in normal ranges and probably can be considered as an early indicator of anthracycline-induced cardiotoxicity.
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| Descriptor
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Echocardiography
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Heart Ventricles
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Breast Neoplasms
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Anthracyclines
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Drug Therapy
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Asymptomatic Diseases
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Abdar Esfahani, Morteza, Thesis advisor
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Mokarian, Fariborz, Thesis advisor
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| Translated Title Supplied by Cataloguer
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تغییرات در پارامترهای اکوکاردیوگرافی از بطن راست در بیماران مبتلا به سرطان پستان بدون علامت در طول شیمی درمانی آنتراسیکلین
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