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" Neurodevelopmental outcome of Patients with West syndrome "
\ Maryam Kachuei
; Jafar Nasiri, Rasool Kermani
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Isfahan University of Medical Sciences
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| Document Type
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Latin Dissertation
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| Language of Document
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English
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| Record Number
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107783
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| Doc. No
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T17147
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| Call number
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WS340,K11n,2016
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| Main Entry
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Kachuei, Maryam
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| Title & Author
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Neurodevelopmental outcome of Patients with West syndrome\ Maryam Kachuei
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| College
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Schools, Medical
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| Date
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, 2016
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| Degree
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Speciality
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| field of study
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Pediatrics
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| Page No
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15P.: tab
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| Note
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This is a research dissertation with project ID: 394628
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مریم کچویی
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| Abstract
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Background: The aim of this study was to investigate the clinical characteristics and neurodevelopmental outcomes of children with west syndrome (WS) using Bayley-III scale of infant development, as the first report from the Middle-East.Methods: In the time period of January 2013 to February 2016, we prospectively enrolled 67 consecutive patients with confirmed diagnosis of WS from Isfahan, Iran. Cognition, language and motor outcomes of the studied subjects were evaluated with the Bayley Scales of Infant and Toddler Development -Third Edition (Bayley-III). Results: Overall, 67 cases were enrolled who were consisted of 34 (50.7%) boys and 33 (49.3%) girls (Male/Female ratio: 1.03). The mean age was 26.7 ± 12.9 months. In the subjects, 50 (74.6 %) patients had symptomatic WS, and 17 (25.4%) patients had cryptogenic WS. "Severe delay" was found in 76.9% of the patients in cognitive evaluation, 67.7% of the patients in language and communication abilities, and, 81.5% in motor function. The patients with cryptogenic WS were significantly more likely to have more favorable outcome in motor (p=0.035), cognitive (p=0.035) and receptive language (p=0.43) in comparison with those who had symptomatic WS. The patients with controlled seizure were significantly more likely to have more favorable outcome in motor (p=0.027) and cognition (p=0.011) compared to those with uncontrolled seizures.Conclusion: WS was associated with poor neurodevelopmental outcome in our study. Severe developmental delay was associated with two major factors: (i) presence of a specific underlying abnormality (symptomatic WS), and, ( ii) persistent seizures as a result of the former.
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| Descriptor
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Spasms, Infantile
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Epilepsy, Generalized
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Cognition
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Neurodevelopmental Disorders
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Infant, Newborn
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| Added Entry
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Nasiri, Jafar, Thesis advisor
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Kermani, Rasool, Thesis advisor
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| Translated Title Supplied by Cataloguer
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نتایج عصبی تکاملی بیماران مبتلا به سندرم وست
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